Neuroleptic drug effects on cognitive function in schizophrenia.
Neuroleptic drug effects on cognitive function in schizophrenia.
复制标题
抗精神病药物对精神分裂症认知功能的影响。
DOI：
10.1016/0920-9964(90)90038-9
复制
发表时间：
1990
影响因子：
4.5
通讯作者：
Brown,GM
中科院分区：
文献类型：
--
作者：
Cleghorn,JM;Kaplan,RD;Szechtman,B;Szechtman,H;Brown,GM
对37例精神分裂症患者、27例未治疗精神分裂症患者和27例正常对照者进行神经心理测验。抗精神病药物治疗的患者在回忆复杂图形、计划迷宫测试方面的表现明显不如未治疗的患者，并且精细运动协调性较差。对照组和未治疗的患者在这些测试中表现同样良好。在16名服用低剂量benztropine的精神抑制剂治疗患者中，结果没有改变，也没有38名报告先前药物滥用的患者，在帕金森病中观察到类似的认知障碍，并与精神分裂症患者的多巴胺能拮抗剂药物有关。因此，他们并不构成精神分裂症缺陷状态的一部分。与对照组相比，治疗组和未治疗组的反应时间更慢，变化更大。两个患者组对转述段落的回忆都明显低于对照组，这一发现在智商匹配的亚组中表现得很强。抗精神病药物治疗与该测试的显著更好表现相关。
Neuropsychological test performance was compared in 37 neuroleptic treated DSM-III schizophrenic patients, 27 untreated schizophrenic patients, and 27 normal controls. Neuroleptic treated patients performed significantly less well than untreated patients at recalling a complex figure, at planning on a mazes test, and had poorer fine motor coordination. Controls and untreated patients performed equally well on these tests. The results were not altered in 16 neuroleptic treated patients who had been prescribed low doses of benztropine, nor 38 patients who reported prior substance abuse.Similar cognitive impairments are observed in Parkinson's disease and are associated with dopaminergic antogonist drugs in schizophrenics. Therefore, they do not comprise part of the Schizophrenic Deficit State.Two tests were better performed by controls than patients. Reaction time was slower and more variable in both treated and untreated patient groups than controls. The recall of paraphrased passages was significantly poorer in both patient groups than controls, a finding that is robust in subgroups matched for IQ. Neuroleptic treatment was associated with significantly better performance on this test.