Dietary prenatal choline supplementation alters postnatal hippocampal structure and function
Dietary prenatal choline supplementation alters postnatal hippocampal structure and function
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DOI：
10.1152/jn.00785.2003
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发表时间：
2004-04-01
影响因子：
2.5
通讯作者：
Swartzwelder, HS
中科院分区：
文献类型：
--
作者：
Li, Q;Guo-Ross, S;Swartzwelder, HS
胆碱是许多食物中存在的一种化合物，最近被列为人类必需营养素。动物模型研究表明，产前胆碱的可用性会影响神经和认知发育。具体来说，产前补充胆碱已被证明可以增强成年后代的工作记忆和海马长时程增强（LTP）。然而，这些效应背后的细胞机制仍不清楚。在这里，我们报告说，在幼年大鼠（20-25天龄）出生后研究的海马CA1锥体细胞中，在6天妊娠期间补充胆碱会导致更大的兴奋反应性，减少慢后超极化（sAHP），增强后除极电位（ADP），更大的体细胞和更大的海马CA1锥体细胞的基底树突分枝化。这些数据表明，在产前发育的短暂关键时期，膳食补充单一营养素胆碱会改变海马锥体细胞的结构和功能。
Choline, a compound present in many foods, has recently been classified as an essential nutrient for humans. Studies with animal models indicate that the availability of choline during the prenatal period influences neural and cognitive development. Specifically, prenatal choline supplementation has been shown to enhance working memory and hippocampal long-term potentiation (LTP) in adult offspring. However, the cellular mechanisms underlying these effects remain unclear. Here we report that choline supplementation, during a 6-day gestational period, results in greater excitatory responsiveness, reduced slow afterhyperpolarizations (sAHPs), enhanced afterdepolarizing potentials (ADPs), larger somata, and greater basal dendritic arborization among hippocampal CA1 pyramidal cells studied postnatally in juvenile rats (20 - 25 days of age). These data indicate that dietary supplementation with a single nutrient, choline, during a brief, critical period of prenatal development, alters the structure and function of hippocampal pyramidal cells.