Detection and genotyping of GBV-C virus in the united Arab emirates
Detection and genotyping of GBV-C virus in the united Arab emirates
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DOI：
10.1002/jmv.20394
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发表时间：
2005-08-01
影响因子：
12.7
通讯作者：
Ezzeddine, SA
中科院分区：
文献类型：
--
作者：
Abu Odeh, RO;Al-Moslih, MI;Ezzeddine, SA
GB virus-C/Hepatitis G virus (GBV-C/HGV), collectively known as GBV-C, is spread widely and has been reported to be associated with non A-E hepatitis. The aim of the current project was to determine the rate of infection and genotypic characteristics of GBV-C in the United Arab Emirates (UAE). A total of 379 plasma/serum samples representing different populations in the UAE and comprising healthy as well as patients positive for HBV and HCV were screened using RT-PCR/nested PCR of the 5'-untranslated region (UTR). National subjects (n = 168) and non-nationals residing in the UAE (n=211) were tested. The results obtained showed that the rate of GBV-C infection in healthy nationals, and those positive for HCV or HBV were 11.1%, 14.3%, and 5.7%, respectively, compared to 8.3%, 33.3%, and 8.6%, respectively, in non-nationals. No statistically significant correlation between infection with GBV-C and HCV or HBV (P > 0.05) was found. Sequence analysis of the 5'-UTR using 37 and 46 clones from 8 and 6 healthy nationals and non-nationals, respectively, revealed the prevalence of the European/North American genotype 2 when compared to the five reference genotypes in GenBank. (c) 2005 Wiley-Liss, Inc.
