TP53 rs1042522 C>G polymorphism and Wilms tumor susceptibility in Chinese children: a four-center case-control study
TP53 rs1042522 C>G polymorphism and Wilms tumor susceptibility in Chinese children: a four-center case-control study
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TP53 rs1042522 C>G 多态性与中国儿童肾母细胞瘤易感性：四中心病例对照研究
DOI：
10.1042/bsr20181891
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发表时间：
2019-01-31
影响因子：
4
通讯作者：
Wang, Jiaxiang
中科院分区：
文献类型：
--
作者：
Liu, Peng;Zhuo, Zhenjian;Wang, Jiaxiang
肾母细胞瘤是儿童最常见的肾脏恶性肿瘤。TP53基因被认为是一种通过控制细胞生长而发挥抑瘤作用的基因。TP53基因rs1042522 C>G（Arg72Pro）多态性在各种类型的癌症中被广泛研究。然而，TP53 rs1042522 C>G多态性是否是肾母细胞瘤风险的候选变异尚不确定。本研究的目的是确定TP53 rs1042522 C>G多态性是否与中国儿童肾母细胞瘤的风险有关。对来自中国4个中心的355例病例和1070例对照进行rs1042522 C>G多态性基因分型。采用logistic回归模型分析rs1042522 C>G多态性对肾母细胞瘤患病率的影响。我们未能检测到rs1042522 C>G多态性与肾母细胞瘤风险之间的显著关系。进一步的分层分析也无法检测到显著的相关性。我们认为TP53 rs1042522 C>G多态性可能对肾母细胞瘤的风险没有足够的影响。需要更多的验证研究，更大的样本量，以更好地确定TP53 rs1042522 C>G多态性在肾母细胞瘤风险中的作用。
Wilms tumor is the most common renal malignancy that occurs in children. TP53 gene is considered as a tumor-suppressing gene through controlling cell growth. TP53 gene rs1042522 C>G (Arg72Pro) polymorphism is widely investigated in various types of cancers. However, it is not established if TP53 rs1042522 C>G polymorphism is a candidate variant for Wilms tumor risk. The aim of the study was to determine whether TP53 rs1042522 C>G polymorphism is responsible for the risk of Wilms tumor in Chinese children. All subjects ( 355 cases and 1070 controls) from four centers of China were genotyped for rs1042522 C>G polymorphism. The effect of rs1042522 C>G polymorphism on Wilms tumor prevalence was analyzed using logistic regression models. We failed to detect a significant relationship between rs1042522 C>G polymorphism and Wilms tumor risk. Further stratification analysis also could not detect a significant relationship. We conclude that TP53 rs1042522 C>G polymorphism might not have enough impact on the risk of Wilms tumor. More validation study with larger sample size will be required to better define the role of TP53 rs1042522 C>G polymorphism in Wilms tumor risk.