The carbohydrate ligands on the host embryo mediate intercellular migration of the parasitic wasp embryo
The carbohydrate ligands on the host embryo mediate intercellular migration of the parasitic wasp embryo
复制标题
宿主胚胎上的碳水化合物配体介导寄生黄蜂胚胎的细胞间迁移
DOI：
10.1016/j.febslet.2011.05.055
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发表时间：
2011
期刊：
影响因子：
3.5
通讯作者：
K
中科院分区：
文献类型：
--
作者：
A. Takahashi-Nakaguchi;T. Hiraoka;K
入侵阶段的寄生蜂Copidosoma floridanum的胚胎通过上皮细胞的遗传学上的远距离宿主胚胎的方式，是类似于哺乳动物白细胞浸润。宿主胚胎细胞似乎通过细胞表面的成分来识别入侵的黄蜂胚胎。我们建立了一种体外黄蜂进入抑制试验，发现黄蜂胚胎的C型凝集素与宿主胚胎表面的岩藻糖残基的N-连接糖链结合。这是第一次报告显示异源多细胞生物之间的受体-配体相互作用。
Invasive stage embryos of the parasitic wasp Copidosoma floridanum transmigrate through the epithelium of phylogenetically distant host embryos in a manner that is similar to mammalian leukocyte infiltration. Host embryonic cells appear to recognize the invading wasp embryo by components on the cell surface. We developed an in vitro wasp entry inhibition assay and found that C-type lectins of the wasp embryo bound to N-linked carbohydrate chains with fucose residues on the surface of host embryo. This is the first report showing a receptor–ligand interaction between heterologous multicellular organisms.