Preserved neural correlates of priming in old age and dementia
Preserved neural correlates of priming in old age and dementia
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DOI：
10.1016/j.neuron.2004.04.002
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发表时间：
2004-06-10
期刊：
影响因子：
16.2
通讯作者：
Buckner, RL
中科院分区：
文献类型：
--
作者：
Lustig, C;Buckner, RL
内隐记忆，包括启动，可以保存在老化和痴呆症，尽管外显记忆受损。为了探索保留记忆能力的神经相关性，在重复启动范式中使用全脑功能MRI（fMRI）研究34名年轻人，33名无痴呆的老年人和24名老年人在阿尔茨海默型痴呆（DAT）的早期阶段。两个老年人组表现出重复为基础的反应时间的好处（启动）和变化的激活沿着额下回类似的年轻人。在所有三组中，重复相关的反应时间减少与前额叶活动减少相关，表明启动和fMRI测量的活动变化之间存在直接关系。这些结果表明，尽管有刻意记忆的困难，但没有痴呆症的老年人和早期DAT患者都可以修改由前额叶贡献介导的行为，使这些保留的能力成为认知训练和康复的有吸引力的目标。
Implicit memory, including priming, can be preserved in aging and dementia despite impairment of explicit memory. To explore the neural correlates of preserved memory ability, whole-brain functional MRI (fMRI) was used during a repetition priming paradigm to study 34 young adults, 33 older adults without dementia, and 24 older adults in the early stages of dementia of the Alzheimer type (DAT). Both older adult groups showed repetition-based response time benefits (priming) and changes in activation along inferior frontal gyrus similar to those shown by young adults. Across all three groups, repetition-related response time reductions correlated with prefrontal activity reductions, demonstrating a direct relation between priming and fMRI-measured activity change. These results suggest that despite difficulties with deliberate memory, both older adults without dementia and those with early-stage DAT can modify behavior mediated by prefrontal contributions, making these preserved abilities an attractive target for cognitive training and rehabilitation.