Dissipative interactions in cell–matrix adhesion
Dissipative interactions in cell–matrix adhesion
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DOI：
10.1039/c3sm50803j
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发表时间：
2013-06
期刊：
影响因子：
3.4
通讯作者：
Christina Müller;A. Müller;T. Pompe
中科院分区：
文献类型：
--
作者：
Christina Müller;A. Müller;T. Pompe
细胞微环境、细胞本身和连接的生物分子成分的机械性质越来越被认为是理解和控制细胞行为的重要参数。具体地说，细胞黏附--相互作用的第一步--控制着细胞信号传递中的许多过程。在此背景下，必须将所涉及的生物聚合物体系的粘弹性特征视为理解其潜在机制的关键。虽然弹性目前在生物物理和生物材料科学中得到了很大的关注，但对粘性和耗散贡献的研究却很少，其影响往往被忽视。在这篇综述中，我们指出有必要克服这种不平衡，并揭示细胞-基质相互作用中耗散过程的影响。
The mechanical properties of cell microenvironments, cells themselves and the linking biomolecular constituents are increasingly recognized as important parameters in understanding and controlling cell behaviour. Specifically, cell adhesion – the first step of interaction – controls many processes in cell signalling. In this context the viscoelastic characteristics of involved biopolymer systems have to be considered as a key to the understanding of the underlying mechanisms. While elasticity is currently heavily addressed in biophysical and biomaterials science, studies on viscous and dissipative contributions are underrepresented and their impact is frequently neglected. In this review we point out that there is a need to overcome this imbalance and to reveal the impact of dissipative processes in cell–matrix interaction.