The miR-290-295 cluster as multi-faceted players in mouse embryonic stem cells.
The miR-290-295 cluster as multi-faceted players in mouse embryonic stem cells.
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miR-290-295 簇在小鼠胚胎干细胞中扮演多面角色
DOI：
10.1186/s13578-017-0166-2
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发表时间：
2017
影响因子：
7.5
通讯作者：
Wu JF
中科院分区：
文献类型：
--
作者：
Yuan K;Ai WB;Wan LY;Tan X;Wu JF
越来越多的证据表明，胚胎干细胞特异性microRNAs（miRNAs）在胚胎早期发育过程中发挥着重要作用。其中，miR-290-295簇在小鼠胚胎干细胞中表达最高，参与多种生物学过程。本文就miR-290-295簇在胚胎干细胞中的功能研究进展作一综述。miR-290-295簇参与调节胚胎干细胞多能性维持、自我更新和将体细胞重编程为胚胎干细胞样状态。此外，miR-290-295簇在胚胎干细胞中具有潜在的促生存功能，参与肿瘤的发生和衰老，具有重要意义。阐明miR-290-295簇与其他基因调控模式之间的相互作用将为我们提供多能干细胞生物学的新思路。在不久的将来，miRNA簇在干细胞领域将展现出广阔的应用前景，如通过瞬时导入组织特异性的miRNA簇，高效改变细胞的身份。
Increasing evidence indicates that embryonic stem cell specific microRNAs (miRNAs) play an essential role in the early development of embryo. Among them, the miR-290-295 cluster is the most highly expressed in the mouse embryonic stem cells and involved in various biological processes. In this paper, we reviewed the research progress of the function of the miR-290-295 cluster in embryonic stem cells. The miR-290-295 cluster is involved in regulating embryonic stem cell pluripotency maintenance, self-renewal, and reprogramming somatic cells to an embryonic stem cell-like state. Moreover, the miR-290-295 cluster has a latent pro-survival function in embryonic stem cells and involved in tumourigenesis and senescence with a great significance. Elucidating the interaction between the miR-290-295 cluster and other modes of gene regulation will provide us new ideas on the biology of pluripotent stem cells. In the near future, the broad prospects of the miRNA cluster will be shown in the stem cell field, such as altering cell identities with high efficiency through the transient introduction of tissue-specific miRNA cluster.
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影响因子：
4.5
作者：
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通讯作者：
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14.9
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