A review of the antimicrobial activity of chitosan
A review of the antimicrobial activity of chitosan
复制标题
DOI：
10.1590/s0104-14282009000300013
复制
发表时间：
2009-01-01
期刊：
影响因子：
--
通讯作者：
Assis, Odilio B. G.
中科院分区：
文献类型：
--
作者：
Goy, Rejane C.;Britto, Douglas de;Assis, Odilio B. G.
壳聚糖是一种来源于甲壳素的多功能亲水性多糖，具有广谱抗菌作用，革兰氏阴性菌、革兰氏阳性菌和真菌对它高度敏感。在目前的审查中，三种可能的和公认的壳聚糖抗菌机制，并简要讨论。活性依赖于聚合物的分子量（MW）和乙酰化度（DA）进行了描述。根据文献中的最新数据总结了壳聚糖的最低抑菌浓度（MIC）。并讨论了水溶性壳聚糖衍生物对细菌生长抑制的潜力。数据表明，壳聚糖的有效性各不相同，并取决于目标微生物的种类。
Chitosan, a versatile hydrophilic polysaccharide derived from chitin, has a broad antimicrobial spectrum to which gram-negative, gram-positive bacteria and fungi are highly susceptible. In the current review, three possible and accepted antimicrobial mechanisms for chitosan are presented and briefly discussed. The activity dependence on polymeric molecular weight (MW) and degree of acetylation (DA) are described. The chitosan minimum inhibitory concentrations (MIC) are summarized according to recent data found in the literature. The potential to improve inhibitory growth of bacteria by using water soluble chitosan derivatives is also discussed. The data indicate that the effectiveness of chitosan varies and is dependent on species of target microorganisms.