Clinical impact of single-fiber electromyography
Clinical impact of single-fiber electromyography
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DOI：
10.1002/mus10141
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发表时间：
2002-01-01
期刊：
影响因子：
3.4
通讯作者：
Sanders, DB
中科院分区：
文献类型：
--
作者：
Sanders, DB
单纤维肌电图的主要临床影响来自其在确认或排除重症肌无力（MG）诊断中的作用。抖动测量在显示MG和Lambert-Eaton肌无力综合征患者疾病严重程度的变化、显示神经和肌肉疾病患者运动单位结构和生理学的细微变化以及显示局部注射肉毒杆菌毒素的远期效应方面也具有临床作用。除了这些临床作用，识别单个肌纤维活动的能力使得标记单个运动单位的放电成为可能。这一点，沿着通过抖动和纤维密度测量获得的信息，独特地增加了我们对正常和疾病状态下运动单位组织和功能的理解。(C)2002 Wiley Periodicals，Inc.
The major clinical impact of single-fiber electromyography has been from its role in confirming, or excluding, the diagnosis of myasthenia gravis (MG). Jitter measurements also have a clinical role in demonstrating changes in disease severity in patients with MG and Lambert-Eaton myasthenic syndrome, in demonstrating subtle changes in motor unit architecture and physiology in patients with nerve and muscle diseases, and in demonstrating the remote effects of locally injected botulinum toxin. In addition to these clinical roles, the ability to identify the activity from single muscle fibers makes it possible to mark the discharges of single motor units. This, along with information gained by jitter and fiber-density measurements, has uniquely increased our understanding of motor unit organization and function in normal and disease states. (C) 2002 Wiley Periodicals, Inc.