Early and late onset sepsis in late preterm infants.
Early and late onset sepsis in late preterm infants.
复制标题
DOI：
10.1097/inf.0b013e3181acf6bd
复制
发表时间：
2009-12
期刊：
影响因子：
--
通讯作者：
Smith PB
中科院分区：
文献类型：
--
作者：
Cohen-Wolkowiez M;Moran C;Benjamin DK;Cotten CM;Clark RH;Benjamin DK Jr;Smith PB
早产在全球范围内不断增加，而占所有早产70%以上的晚期早产占了大部分增长。早发型和晚发型脓毒症导致极早产儿的显著死亡率，但对晚发型早产儿脓毒症的结局知之甚少。这是一项观察性队列研究，研究对象为1996年至2007年期间在美国248个新生儿重症监护病房住院的出生时估计胎龄在34至36周之间的< 121天的婴儿（119，130名出生时≤ 3天的婴儿和106，142名出生时4至120天的婴儿）。在研究期间，早发性和迟发性脓毒症的累积发病率分别为4.42和6.30次/1000例入院。革兰氏阳性菌引起大多数早发性和迟发性脓毒症发作。革兰氏阴性杆菌引起的早发性脓毒症婴儿和迟发性脓毒症婴儿比无菌血培养的同龄人更容易死亡（OR分别为4.39，95%CI 1.71-11.23，P=0.002; OR 3.37，95%CI 2.35-4.84，P<0.001）。晚期早产儿表现出与早发型和晚发型脓毒症相关的特定感染率、病原体分布和死亡率。本研究的结果可推广到特殊护理托儿所或新生儿重症监护室的晚期早产儿。
Preterm birth is increasing worldwide, and late preterm births, which comprise more than 70% of all preterm births, account for much of the increase. Early and late onset sepsis results in significant mortality in extremely preterm infants, but little is known about sepsis outcomes in late preterm infants. This is an observational cohort study of infants < 121 days of age (119,130 infants less than or equal to 3 days of life and 106,142 infants between 4 and 120 days of life) with estimated gestational age at birth between 34 and 36 weeks, admitted to 248 neonatal intensive care units in the United States between 1996 and 2007. During the study period, the cumulative incidence of early and late onset sepsis was 4.42 and 6.30 episodes per 1000 admissions, respectively. Gram-positive organisms caused the majority of early and late onset sepsis episodes. Infants with early onset sepsis caused by Gram-negative rods and infants with late onset sepsis were more likely to die than their peers with sterile blood cultures (OR 4.39, 95% CI 1.71–11.23, P=0.002; and OR 3.37, 95% CI 2.35–4.84, P<0.001, respectively). Late preterm infants demonstrate specific infection rates, pathogen distribution, and mortality associated with early and late onset sepsis. The results of this study are generalizable to late preterm infants admitted to the special care nursery or neonatal intensive care unit.
登录
查看更多内容
影响因子：
2.4
作者：
Aziz K;McMillan DD;Andrews W;Pendray M;Qiu Z;Karuri S;Lee SK;Canadian Neonatal Network
通讯作者：
Canadian Neonatal Network
影响因子：
168.9
作者：
Barros, FC;Victora, CG;Vaughan, JP
通讯作者：
Vaughan, JP
影响因子：
8
作者：
Benjamin, DK;Stoll, BJ;Goldberg, R
通讯作者：
Goldberg, R
影响因子：
8
作者：
Shapiro-Mendoza, Carrie K.;Tomashek, Kay M.;Declercq, Eugene
通讯作者：
Declercq, Eugene
影响因子：
4.5
作者：
Cordero, L;Sananes, M;Ayers, LW
通讯作者：
Ayers, LW