Vitamin D receptor signaling and pancreatic cancer cell EMT.
Vitamin D receptor signaling and pancreatic cancer cell EMT.
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DOI：
10.2174/1381612821666141211151138
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发表时间：
2015
影响因子：
3.1
通讯作者：
Zheng S
中科院分区：
文献类型：
--
作者：
Li Z;Guo J;Xie K;Zheng S
胰腺导管腺癌仍然是人类最致命的恶性肿瘤之一。即使在接受切除术的患者中，长期生存率仍然非常低。胰腺导管腺癌侵袭性的主要贡献者是上皮-间充质转化（EMT），这是癌细胞从上皮表型到间充质表型的形态和遗传变化的生理过程，其是胰腺癌细胞高转移潜力的基础。EMT由多种肿瘤微环境因素触发，包括细胞因子、生长因子和化疗剂。这篇综述强调了EMT对胰腺癌进展的影响的越来越多的证据，重点是EMT与癌症进展的其他途径，特别是维生素D受体信号的相互作用。在这些疾病过程中导致EMT程序失活的信号通路的研究为细胞表型的可塑性和可能的治疗干预提供了新的见解。
Pancreatic ductal adenocarcinoma remains one of the most lethal of human malignancies. Even in patients who undergo resection, long-term survival rates remain extremely low. A major contributor to the aggressiveness of pancreatic ductal adenocarcinoma is epithelial-to-mesenchymal transition (EMT), a physiologic process of morphological and genetic changes in carcinoma cells from an epithelial phenotype to a mesenchymal phenotype, which is the basis of the high metastatic potential of pancreatic cancer cells. EMT is triggered by various tumor microenvironmental factors, including cytokines, growth factors, and chemotherapeutic agents. This review highlights the growing evidence of the effect of EMT on pancreatic cancer progression, focusing on the interaction of EMT with other pathways central to cancer progression, especially vitamin D receptor signaling. Studies of the signaling pathways that lead to the inactivation of EMT programs during these disease processes are providing new insights into the plasticity of cellular phenotypes and possible therapeutic interventions.