Hippocampal atrophy relates to fluid intelligence decline in the elderly.
Hippocampal atrophy relates to fluid intelligence decline in the elderly.
复制标题
DOI：
10.1017/s135561771000127x
复制
发表时间：
2011-01
影响因子：
2.6
通讯作者：
Stern, Yaakov
中科院分区：
文献类型：
--
作者：
Reuben, Aaron;Brickman, Adam M.;Muraskin, Jordan;Steffener, Jason;Stern, Yaakov
对40名健康年轻人（年龄18-30岁）和36名健康老年人（年龄60-83岁）的大脑和海马体积测量结果与三个概念领域的复合认知功能评分进行了比较：记忆能力，处理速度和一般流体智力。通过一系列的一般线性模型测试这些大脑措施和认知成绩之间的关系，海马体积和流体智力能力之间的显着正相关关系被发现在老年人，但不是在年轻人。其他认知领域与大脑或海马体积之间没有关系，研究结果表明海马萎缩在老年人液体智力下降中起作用。
Measures of brain and hippocampal volume in 40 healthy young (aged 18–30 years) and 36 healthy elderly (aged 60–83 years) subjects were compared with composite cognitive function scores in three conceptual domains: memory ability, processing speed, and general fluid intelligence. Through a series of general linear models testing the relationship between these brain measures and cognitive performance scores, a significant positive relationship between hippocampal volume and fluid intelligence ability was found in elderly subjects but not in young. No relationship between the other cognitive domains and brain or hippocampal volume was found. The findings suggest a role of hippocampal atrophy in the decline in fluid intelligence in the elderly.