The mouse Hox-1.3 gene is functionally equivalent to the Drosophila Sex combs reduced gene.
The mouse Hox-1.3 gene is functionally equivalent to the Drosophila Sex combs reduced gene.
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小鼠 Hox-1.3 基因在功能上等同于果蝇性梳减少基因。
DOI：
10.1101/gad.7.3.343
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发表时间：
1993
影响因子：
10.5
通讯作者：
Pick,L
中科院分区：
文献类型：
--
作者：
Zhao,JJ;Lazzarini,RA;Pick,L
小鼠Hox-1.3和三种果蝇同源结构域蛋白（8 cr、Antp和Dfd）在同源结构域中高度同源（图1A）。此外，另外两个短区域（Odenwald等，1987），一个在蛋白质的氨基末端（八肽），另一个紧邻同源结构域（五肽），在这些蛋白质中也高度保守。然而，270个氨基酸的Hox-1.3蛋白与这三种蛋白的总体相似性较低：28%（75个氨基酸）与Scr; 26%（70个氨基酸）与Antp; 24%（66个氨基酸）与变形（Dfd）。由于Hox-1的序列相似度和位置略高，3在
The mouse Hox-1.3 and three Drosophila homeo domain proteins (8cr, Antp, and Dfd) are highly homologous in the homeo domain (Fig. 1A). In addition, two other short regions (Odenwald et al. 1987), one at the amino terminus of the proteins (the octapeptide) and the other just adjacent to the homeo domain (the pentapeptide), are also highly conserved among these proteins. However, the overall similarity of the 270-amino-acid Hox-1.3 protein to the three is low: 28%(75 amino acids) to Scr; 26%(70 amino acids) to Antp; and 24%(66 amino acids) to Deformed (Dfd). Because of the slightly higher degree of sequence similarity and the position of Hox-l. 3 in the