Factors promoting vulnerability to dysregulated stress reactivity and stress-related disease.
Factors promoting vulnerability to dysregulated stress reactivity and stress-related disease.
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DOI：
10.1111/jne.12641
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发表时间：
2018-10
影响因子：
3.2
通讯作者：
Deak T
中科院分区：
文献类型：
--
作者：
Russell AL;Tasker JG;Lucion AB;Fiedler J;Munhoz CD;Wu TJ;Deak T
生物应激反应的有效协调对于生物体的行为健康是不可或缺的。应激反应通过神经内分泌系统和交感神经系统的相互作用来协调。下丘脑-垂体-肾上腺(HPA)轴在协调机体对应激的反应中起着关键作用，该轴的活动可以被广泛的经验事件所改变。本文将重点介绍影响HPA轴反应性的几个因素。其中一些因素包括早年的生活逆境、暴露在慢性压力下、免疫激活和创伤性脑损伤。中心前提是，这些经历中的每一种都是一般性的脆弱因素，它们加速了未来HPA轴的反应，使个人对压力挑战更加敏感，从而前馈到正在进行的或更容易受到未来应激相关疾病状态的恶化，特别是当它们与负面影响和整体大脑健康有关时。
Effective coordination of the biological stress response is integral for the behavioral well-being of an organism. Stress reactivity is coordinated by an interplay of the neuroendocrine system and the sympathetic nervous system. The hypothalamus-pituitary-adrenal (HPA) axis plays a key role in orchestrating bodily responses to stress, and activity of the axis can be modified by a wide range of experiential events. This review will focus on several factors that influence subsequent HPA axis reactivity. Some of these factors include early life adversity, exposure to chronic stress, immune activation, and traumatic brain injury. The central premise is that each of these experiences serve as general vulnerability factors that accelerate future HPA axis reactivity in ways that make individuals more sensitive to stress challenges, and therefore feed forward into exacerbation of ongoing, or greater susceptibility toward, future stress-related disease states, especially as they pertain to negative affect and overall brain health.