Control of developmental transitions in the cyclic AMP signalling system of Dictyostelium discoideum.
Control of developmental transitions in the cyclic AMP signalling system of Dictyostelium discoideum.
复制标题
盘基网柄菌环状 AMP 信号系统发育转变的控制。
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
Lee A. Segel
中科院分区：
文献类型：
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作者：
Albert Goldbeter;Lee A. Segel
在饥饿后的最初几个小时内，观察到盘基网柄藻cAMP分泌系统的发育依次处于以下四种状态之一：（a）静止，（B）兴奋（能够接力），（c）自主振荡，（d）以高稳定水平分泌。提出了一个理论模型，该模型表明不同类型行为之间转变的最接近原因可能是腺苷酸环化酶和磷酸二酯酶活性的缓慢变化。这些变化影响cAMP信号系统所允许的稳态的稳定性。当稳态不稳定时，产生持续的振荡，而cAMP信号的中继发生在稳定稳态的参数值接近产生振荡的参数值的扰动时。建议在腺苷酸环化酶-磷酸二酯酶空间的顺序过渡的发展路径相比，观察到这些酶的合成饥饿后的时间过程。有人建议，有一般意义的理解分化的例子中给出的状态点以下的参数空间中的发展路径，从一个行为域移动到另一个，从而带来转变的定性行为。
In the first few hours after starvation, the developing cAMP secretory system in Dictyostelium discoideum has been observed to be successively in one of four states: (a) quiescent, (b) excitable (capable of relay), (c) autonomously oscillating, and (d) secreting at a high steady level. A theoretical model is presented which demonstrates that the proximal cause of the transitions between different types of behavior may be slow changes in the activities of the enzymes adenylate cyclase and phosphodiesterase. These changes affect the stability properties of the steady state admitted by the cAMP signalling system. Sustained oscillations develop when the steady state is unstable, whereas relay of cAMP signals occurs upon perturbation of a stable steady state for parameter values close to those which produce oscillations. The developmental path suggested in the adenylate cyclase-phosphodiesterase space for the sequential transitions compares with the time course observed for the synthesis of these enzymes after starvation. It is suggested that there is general significance for the understanding of differentiation in the example given of a state-point following a developmental path in parameter space, moving from one behavioral domain to another, and thereby bringing about shifts in qualitative behavior.