Clinical characteristics of 3062 COVID-19 patients: A meta-analysis
Clinical characteristics of 3062 COVID-19 patients: A meta-analysis
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DOI：
10.12052/gdutxb.200023
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发表时间：
2020-06-24
影响因子：
12.7
通讯作者：
Zhao, Chunling
中科院分区：
文献类型：
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作者：
Zhu, Jieyun;Ji, Pan;Zhao, Chunling
我们旨在系统回顾2019冠状病毒病（COVID-19）的临床特征。检索了7个数据库，以收集2020年1月1日至2020年2月28日期间有关COVID-19临床特征的研究。采用Stata12.0软件进行Meta分析。共纳入38项研究，涉及3062名COVID-19患者。Meta分析显示，男性感染者比例较高（56.9%）。呼吸衰竭或急性呼吸窘迫综合征的发生率为19.5%，病死率为5.5%。临床表现以发热（80.4%）、乏力（46%）、咳嗽（63.1%）、咳痰（41.8%）最为常见。其他常见症状有肌肉酸痛（33%）、厌食（38.8%）、胸闷（35.7%）、气短（35%）、呼吸困难（33.9%）。次要症状包括恶心呕吐（10.2%）、腹泻（12.9%）、头痛（15.4%）、咽痛（13.1%）、寒战（10.9%）和腹痛（4.4%）。无症状的患者比例为11.9%。白细胞计数正常（69.7%），淋巴细胞减少（56.5%），C反应蛋白升高（73.6%），ESR升高（65.6%），氧合指数降低（63.6%）。37.2%的患者出现D-二聚体升高，25.9%的患者出现白细胞减少，29%的患者出现肝功能异常，25.5%的患者出现肾功能异常。其他发现包括白细胞增多（12.6%）和降钙素原升高（17.5%）。仅25.8%的患者病变累及单肺，75.7%的患者病变累及双肺。COVID-19患者最常见的症状是发热、疲劳、咳嗽和咳痰。相对较小比例的患者无症状。多数患者白细胞计数正常，淋巴细胞减少，C-反应蛋白和ESR水平升高。双肺受累常见。
We aimed to systematically review the clinical characteristics of coronavirus disease 2019 (COVID-19). Seven databases were searched to collect studies about the clinical characteristics of COVID-19 from January 1, 2020 to February 28, 2020. Then, meta-analysis was performed by using Stata12.0 software. A total of 38 studies involving 3062 COVID-19 patients were included. Meta-analysis showed that a higher proportion of infected patients was male (56.9%). The incidence rate of respiratory failure or acute respiratory distress syndrome was 19.5% and the fatality rate was 5.5%. Fever (80.4%), fatigue (46%), cough (63.1%), and expectoration (41.8%) were the most common clinical manifestations. Other common symptoms included muscle soreness (33%), anorexia (38.8%), chest tightness (35.7%), shortness of breath (35%), dyspnea (33.9%). Minor symptoms included nausea and vomiting (10.2%), diarrhea (12.9%), headache (15.4%), pharyngalgia (13.1%), shivering (10.9%), and abdominal pain (4.4%). The proportion of patients that was asymptomatic was 11.9%. Normal leukocyte counts (69.7%), lymphopenia (56.5%), elevated C-reactive protein levels (73.6%), elevated ESR (65.6%), and oxygenation index decreased (63.6%) were observed in most patients. About 37.2% of patients were found with elevated D-dimer, 25.9% of patients with leukopenia, along with abnormal levels of liver function (29%), and renal function (25.5%). Other findings included leukocytosis (12.6%) and elevated procalcitonin (17.5%). Only 25.8% of patients had lesions involving a single lung and 75.7% of patients had lesions involving bilateral lungs. The most commonly experienced symptoms of COVID-19 patients were fever, fatigue, cough, and expectoration. A relatively small percentage of patients were asymptomatic. Most patients showed normal leucocytes counts, lymphopenia, elevated levels of C-reactive protein and ESR. Bilateral lung involvement was common.