Yeast genome duplication was followed by asynchronous differentiation of duplicated genes
Yeast genome duplication was followed by asynchronous differentiation of duplicated genes
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DOI：
10.1038/nature01419
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发表时间：
2003-02-20
期刊：
影响因子：
64.8
通讯作者：
Piskur, J
中科院分区：
文献类型：
--
作者：
Langkjær, RB;Cliften, PF;Piskur, J
在酵母、植物和人类基因组中观察到了基因冗余，并被认为是全基因组复制的结果(1-3)。面包酵母，酿酒酵母，含有数百个重复的基因(1)。复制(S)可能发生在特定物种形成之前或之后。为了了解酵母基因组的进化，我们分析了其中一些基因在几个相关酵母物种中的同源基因。根据推测的每一组基因的系统发育，我们能够推断该基因在两个酵母谱系分化之前或之后是否复制和/或特化。在这里，我们证明了基因复制可能是作为单个事件发生的，并且它可能发生在酵母和克鲁维酵母谱系彼此分离之前。每对重复基因的进一步进化--如两个拷贝的特化或分化，或单个拷贝的缺失--在这些物种的整个进化过程中都是独立进行的。
Gene redundancy has been observed in yeast, plant and human genomes, and is thought to be a consequence of whole-genome duplications(1-3). Baker's yeast, Saccharomyces cerevisiae, contains several hundred duplicated genes(1). Duplication(s) could have occurred before or after a given speciation. To understand the evolution of the yeast genome, we analysed orthologues of some of these genes in several related yeast species. On the basis of the inferred phylogeny of each set of genes, we were able to deduce whether the gene duplicated and/or specialized before or after the divergence of two yeast lineages. Here we show that the gene duplications might have occurred as a single event, and that it probably took place before the Saccharomyces and Kluyveromyces lineages diverged from each other. Further evolution of each duplicated gene pair-such as specialization or differentiation of the two copies, or deletion of a single copy-has taken place independently throughout the evolution of these species.