A novel macrolide, solithromycin suppresses mucin overexpression induced by Pseudomonas aeruginosa LPS in airway epithelial cells
A novel macrolide, solithromycin suppresses mucin overexpression induced by Pseudomonas aeruginosa LPS in airway epithelial cells
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DOI：
10.1016/j.jiac.2020.06.014
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发表时间：
2020-09-01
影响因子：
2.2
通讯作者：
Yanagihara, Katunori
中科院分区：
文献类型：
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作者：
Kawamoto, Yasuhide;Morinaga, Yoshitomo;Yanagihara, Katunori
一些大环内酯类如14-和15-元大环内酯类具有免疫调节作用，如抑制粘蛋白过度产生。由于开发了一种新的大环内酯类药物索利霉素，我们研究了它是否能抑制体外粘蛋白的过度表达。铜绿假单胞菌脂多糖刺激人气道上皮细胞系NCLeH 292，诱导主要粘蛋白MUC 5AC的过度产生。用10 mg/mL索利霉素以及15元大环内酯阿奇霉素处理在mRNA和蛋白质水平上显著抑制LPS诱导的MUC 5AC。这些发现支持索利霉素具有潜在的免疫调节作用。(C)2020年日本化疗学会和日本传染病协会。由爱思唯尔有限公司出版。保留所有权利。
Some macrolides such as 14- and 15-membered macrolides have immunomodulatory effects such as suppression of mucin overproduction. Because a novel macrolide, solithromycin, was developed, we examined whether it suppresses the overexpression of mucin in vitro. A human airway epithelial cell line NCIeH292 was stimulated by Pseudomonas aeruginosa lipopolysaccharides to induce the overproduction of a major mucin, MUC5AC. Treatment with 10 mg/mL of solithromycin significantly inhibited LPSinduced MUC5AC in both mRNA and protein levels as well as a 15-membered macrolide, azithromycin. These findings support that solithromycin has a potential immunomodulatory effect. (C) 2020 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.