Plasma BDNF concentration, Val66Met genetic variant and depression-related personality traits.
Plasma BDNF concentration, Val66Met genetic variant and depression-related personality traits.
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DOI：
10.1111/j.1601-183x.2010.00579.x
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发表时间：
2010-07
期刊：
影响因子：
--
通讯作者：
Costa PT Jr
中科院分区：
文献类型：
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作者：
Terracciano A;Martin B;Ansari D;Tanaka T;Ferrucci L;Maudsley S;Mattson MP;Costa PT Jr
脑源性神经营养因子（BDNF）调节突触可塑性和神经发生，并且BDNF血浆和血清水平与抑郁症、阿尔茨海默病和其他精神和神经退行性疾病相关。从巴尔的摩老龄化纵向研究（BLSA）中抽取的一个相对较大的社区样本中，我们研究了BDNF血浆浓度是否与BDNF基因的Val 66 Met功能多态性（n = 335）和NEO-PI-R评估的抑郁症相关人格特质（n = 391）相关。在男性或女性中，BDNF的血浆浓度与Val 66 Met变体无关。然而，在男性中，而不是在女性中，BDNF血浆水平与抑郁症相关的人格特质有关。与低BDNF与负面结果相关的概念相反，我们发现在抑郁和易受压力（神经质的两个方面）得分较低的男性中血浆水平较低，而在尽责性和外向性方面得分较高。这些发现挑战了普遍的假设，即较低的外周BDNF水平是抑郁症的标志。
Brain derived neurotrophic factor (BDNF) regulates synaptic plasticity and neurogenesis, and BDNF plasma and serum levels have been associated with depression, Alzheimer's disease, and other psychiatric and neurodegenerative disorders. In a relatively large community sample, drawn from the Baltimore Longitudinal Study of Aging (BLSA), we examine whether BDNF plasma concentration is associated with the Val66Met functional polymorphism of the BDNF gene (n = 335) and with depression-related personality traits assessed with the NEO-PI-R (n = 391). Plasma concentration of BDNF was not associated with the Val66Met variant in either men or women. However, in men, but not in women, BDNF plasma level was associated with personality traits linked to depression. Contrary to the notion that low BDNF is associated with negative outcomes, we found lower plasma levels in men who score lower on depression and vulnerability to stress (two facets of Neuroticism) and higher on Conscientiousness and Extraversion. These findings challenge the prevailing hypothesis that lower peripheral levels of BDNF are a marker of depression.