Enhanced phospholipase A2 activity in rat plasma, liver, and intestinal mucosa following endotoxin treatment: a possible explanation for the protective effect of indomethacin in endotoxic shock.
Enhanced phospholipase A2 activity in rat plasma, liver, and intestinal mucosa following endotoxin treatment: a possible explanation for the protective effect of indomethacin in endotoxic shock.
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内毒素治疗后大鼠血浆、肝脏和肠粘膜中磷脂酶 A2 活性增强：吲哚美辛在内毒素休克中的保护作用的可能解释。
DOI：
10.1016/0026-0495(85)90129-5
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
S. L. Gartner
中科院分区：
文献类型：
--
作者：
K. Shakir;J. O'brian;S. L. Gartner
Endotoxin administration in rats produced a significant increase in plasma, hepatic, and intestinal phospholipase A2activity within three minutes after injection. The elevated phospholipase A2activity seen in these tissues returned to normal levels six minutes after injection. The changes in phospholipase A2activity were dose-dependent within the 0, 10, and 20 mg/kg range of treatment withEscherichia coliendotoxin. This increase in plasma, hepatic, and intestinal phospholipase A2was abolished by prior treatment of the rats with 3 mg/kg indomethacin, a drug known to improve survival in endotoxic shock. The fact that the change in phospholipase A2occurs soon after endotoxin administration and that the change in phospholipase is blocked by protective doses of indomethacin suggests that phospholipase A2activation may be an important initial event in the lethal action of endotoxin, and that the protective effects of indomethacin may be directly related to inhibition of phospholipase A2activity. Further, in vitro studies of the effects of indomethacin on hepatic phospholipase A2activity showed that indomethacin significantly inhibited this enzyme. Indomethacin (25 μmol/L) produced 56% inhibition in phospholipase A2activity and the apparentKifor indomethacin was 9.2 μmol/L. Kinetic analysis using the Lineweaver-Burk method showed that the indomethacin inhibition was of the noncompetitive type.
内毒素耐受中的花生四烯酸代谢。
DOI：
--
发表时间：
1983
期刊：
Advances in shock research
影响因子：
--
作者：
Wise,WC;Cook,JA;Halushka,PV
通讯作者：
Halushka,PV
布洛芬可提高大鼠内毒素休克的存活率。
DOI：
--
发表时间：
1980
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Wise,WC;Cook,JA;Eller,T;Halushka,PV
通讯作者：
Halushka,PV
内毒素对狗心脏磷脂酶 A 活性的刺激。
DOI：
10.1016/0006-2944(82)90055-2
发表时间：
1982
期刊：
Biochemical medicine
影响因子：
--
作者：
Liu,MS;Takeda,H
通讯作者：
Takeda,H