The Generation R Study: design and cohort update 2012
The Generation R Study: design and cohort update 2012
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DOI：
10.1007/s10654-012-9735-1
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发表时间：
2012-09-01
影响因子：
13.6
通讯作者：
Hofman, Albert
中科院分区：
文献类型：
--
作者：
Jaddoe, Vincent W. V.;van Duijn, Cornelia M.;Hofman, Albert
R世代研究是一项基于人群的前瞻性队列研究，从胎儿期到成年期。该研究旨在确定早期环境和遗传原因以及导致胎儿、儿童和成年期正常和异常生长、发育和健康的因果途径。该研究重点关注六个研究领域：（1）孕产妇健康;（2）生长和身体发育;（3）行为和认知发展;（4）呼吸系统健康和过敏;（5）儿童疾病;（6）儿童及其父母的健康和医疗保健。感兴趣的主要风险包括环境、内分泌、遗传和表观遗传、生活方式、营养和社会人口因素。总共有9 778名分娩日期为2002年4月至2006年1月的母亲参加了这项研究。基线反应率为61%，6岁之前的一般随访率超过80%。对母亲、父亲和儿童的数据收集包括问卷调查、详细的身体和超声波检查、行为观察和生物样本。在参与的儿童中可获得基因组和表观基因组广泛关联筛查。从5岁开始，在专门的研究中心进行定期详细的实践评估，包括先进的成像设备，如磁共振成像。最终，R世代研究的结果有助于制定优化孕妇和儿童健康和保健的战略。
The Generation R Study is a population-based prospective cohort study from fetal life until adulthood. The study is designed to identify early environmental and genetic causes and causal pathways leading to normal and abnormal growth, development and health during fetal life, childhood and adulthood. The study focuses on six areas of research: (1) maternal health; (2) growth and physical development; (3) behavioural and cognitive development; (4) respiratory health and allergies; (5) diseases in childhood; and (6) health and healthcare for children and their parents. Main exposures of interest include environmental, endocrine, genetic and epigenetic, lifestyle related, nutritional and socio-demographic determinants. In total, n = 9,778 mothers with a delivery date from April 2002 until January 2006 were enrolled in the study. Response at baseline was 61 %, and general follow-up rates until the age of 6 years exceed 80 %. Data collection in mothers, fathers and children include questionnaires, detailed physical and ultrasound examinations, behavioural observations, and biological samples. A genome and epigenome wide association screen is available in the participating children. From the age of 5 years, regular detailed hands-on assessments are performed in a dedicated research center including advanced imaging facilities such as Magnetic Resonance Imaging. Eventually, results forthcoming from the Generation R Study contribute to the development of strategies for optimizing health and healthcare for pregnant women and children.