Flux distribution of metabolic networks close to optimal biomass production.
Flux distribution of metabolic networks close to optimal biomass production.
复制标题
代谢网络的通量分布接近最佳生物量生产。
DOI：
10.1103/physreve.78.035101
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
G. Bianconi
中科院分区：
文献类型：
--
作者：
G. Bianconi
我们研究了一个描述代谢网络中通量稳态分布的统计模型。定义在连续变量上的所得模型可以通过空腔方法求解。特别是，分析的易处理性是可能的，解决腔方程的网络具有相同的度分布作为一个真实的代谢网络的合奏。优化生物质生产的通量分布具有与底层网络的结构特性无关的幂律指数的厚尾。这些结果与通量平衡分析结果完全一致，并且与实验结果定性一致。
We study a statistical model describing the steady-state distribution of the fluxes in a metabolic network. The resulting model defined on continuous variables can be solved by the cavity method. In particular, analytical tractability is possible, solving the cavity equation over an ensemble of networks with the same degree distribution as a real metabolic network. The flux distribution that optimizes production of biomass has a fat tail with a power-law exponent independent of the structural properties of the underlying network. These results are in complete agreement with the flux-balance-analysis outcome and in qualitative agreement with the experimental results.
DOI：
10.1073/pnas.97.10.5528
发表时间：
2000-05-09
影响因子：
11.1
作者：
Edwards, JS;Palsson, BO
通讯作者：
Palsson, BO