Radiocontrast agents induce endothelin release in vivo and in vitro.
Radiocontrast agents induce endothelin release in vivo and in vitro.
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发表时间：
1992-07
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通讯作者：
Samuel N. Heyman;Barbara Clark;N. Kaiser;Katherine Spokes;Seymour Rosen;M. Brezis;Franklin H. Epstein
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作者：
Samuel N. Heyman;Barbara Clark;N. Kaiser;Katherine Spokes;Seymour Rosen;M. Brezis;Franklin H. Epstein
向大鼠血管内给予离子放射性对比剂碘酞酸钠（2.9克碘/千克体重）诱导免疫反应性内皮素血浆浓度从21.3+/-1.2增加到36+/-3fmol/mL，随后心房钠尿肽血浆水平短暂升高并与RBF下降相关。等碘量的非离子制剂碘沙格酯和碘海醇引起血浆内皮素类似或更显着的变化，但氯化钠、甘露醇或葡萄糖的高渗溶液则不会。输注内皮素-1 产生的内皮素水平可导致 RBF 降低高达 29%。碘酞酸盐和碘海醇刺激培养的牛内皮细胞释放内皮素，表明离子和非离子药物对血管内皮有直接作用。这些数据引发了这样的猜测：在某些情况下，内皮素的释放可能在这些化合物引起的循环变化以及放射性对比肾病的发病机制中发挥作用。
The intravascular administration of the ionic radiocontrast agent sodium iothalamate (2.9 g of iodine/kg body wt) to rats induced an increase in plasma concentration of immunoreactive endothelin from 21.3 +/- 1.2 to 36 +/- 3 fmol/mL, preceded by a transient rise in the plasma level of atrial natriuretic peptide and associated with a fall in RBF. Equi-iodine amounts of the nonionic agents ioxaglate and iohexol elicited similar or more marked changes in plasma endothelin, but hypertonic solutions of NaCl, mannitol, or glucose did not. Comparable levels of endothelin produced by infusions of endothelin-1 induced a reduction of up to 29% in RBF. Iothalamate and iohexol stimulated endothelin release from cultured bovine endothelial cells, suggesting a direct effect of ionic and nonionic agents on vascular endothelium. The data invite speculation that under some circumstances endothelin release might play a role in the circulatory changes caused by these compounds and in the pathogenesis of radiocontrast nephropathy.