Virus interferes with host-seeking behaviour of mosquito
Virus interferes with host-seeking behaviour of mosquito
复制标题
病毒干扰蚊子的寻找宿主行为
DOI：
10.1242/jeb.164186
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发表时间：
2017
影响因子：
2.8
通讯作者：
C. Koenraadt
中科院分区：
文献类型：
--
作者：
C. Vogels;J. Fros;G. Pijlman;J. V. van Loon;G. Gort;C. Koenraadt
病媒病原体的传播依赖于其病媒的宿主寻找行为。病原体操纵病媒对易感宿主的寻找宿主行为，据说有利于传播。对于西尼罗河病毒（WNV），操纵主要蚊子媒介对鸟类的宿主寻找行为将是有利的，因为哺乳动物是死端宿主。我们假设西尼罗河病毒感染诱导了更强的宿主寻找反应和宿主对鸟类的偏好转变，以增强蚊子的传播。然而，在这里，我们表明，西尼罗河病毒感染降低了宿主寻求反应，并没有引起蚊子宿主偏好的转变。其他与健康相关的特征不受西尼罗河病毒感染的影响。西尼罗河病毒感染对触角电生理反应性无影响。因此，减少宿主寻找反应可能是由于干扰蚊子的中枢神经系统。这是第一项研究表明，特别是病原体引起的寻找宿主行为的变化不利于传播。总结：这是第一次，西尼罗河病毒引起的蚊子寻找宿主的行为发生了变化，不利于病毒的传播。
ABSTRACT Transmission of vector-borne pathogens is dependent on the host-seeking behaviour of their vector. Pathogen manipulation of the host-seeking behaviour of vectors towards susceptible hosts is supposedly beneficial for transmission. For West Nile virus (WNV), manipulation of the host-seeking behaviour of the main mosquito vector towards birds would be advantageous, because mammals are dead-end hosts. We hypothesised that WNV infection induces a stronger host-seeking response and a shift in host preference towards birds, to enhance its transmission by mosquitoes. However, here we show that WNV infection decreases the host-seeking response, and does not induce a shift in mosquito host preference. Other fitness-related traits are not affected by WNV infection. No effect of WNV infection was found on antennal electrophysiological responsiveness. Thus, the reduced host-seeking response is likely to result from interference in the mosquito's central nervous system. This is the first study that shows changes, specifically in the host-seeking behaviour induced by a pathogen, that do not favour transmission. Summary: For the first time, changes are shown in the host-seeking behaviour of mosquitoes induced by West Nile virus that do not favour transmission of the virus.