Candidate Gene Association Analysis of Neuroblastoma in Chinese Children Strengthens the Role of LMO1.
Candidate Gene Association Analysis of Neuroblastoma in Chinese Children Strengthens the Role of LMO1.
复制标题
中国儿童神经母细胞瘤候选基因关联分析强化了 LMO1 的作用。
DOI：
10.1371/journal.pone.0127856
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Ni X
中科院分区：
文献类型：
--
作者：
Lu J;Chu P;Wang H;Jin Y;Han S;Han W;Tai J;Guo Y;Ni X
Neuroblastoma (NB) is the most common extra-cranial solid tumor in children and the most frequently diagnosed cancer in the first year of life. Previous genome-wide association studies (GWAS) of Caucasian and African populations have shown that common single nucleotide polymorphisms (SNPs) in several genes are associated with the risk of developing NB, while few studies have been performed on Chinese children. Herein, we examined the association between the genetic polymorphisms in candidate genes and the risk of NB in Chinese children. In total, 127 SNPs in nine target genes, revealed by GWAS studies of other ethnic groups and four related lincRNAs, were genotyped in 549 samples (244 NB patients and 305 healthy controls). After adjustment for gender and age, there were 21 SNPs associated with NB risk at the two-sided P < 0.05 level, 11 of which were located in LMO1. After correction for multiple comparisons, only rs204926 in LMO1 remained significantly different between cases and controls (OR = 0.45, 95% CI: 0.31–0.65, adjusted P = 0.003). In addition, 16 haplotypes in four separate genes were significantly different between case and control groups at an unadjusted P value < 0.05, 11 of which were located in LMO1. A major haplotype, ATC, containing rs204926, rs110420, and rs110419, conferred a significant increase in risk for NB (OR = 1.82, 95% CI: 1.41–2.36, adjusted P < 0.001). The major finding of our study was obtained for risk alleles within the LMO1 gene. Our data suggest that genetic variants in LMO1 are associated with increased NB risk in Chinese children.
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影响因子：
3.7
作者：
Fan QH;Yu R;Huang WX;Cui XX;Luo BH;Zhang LY
通讯作者：
Zhang LY
影响因子：
45.3
作者：
BRODEUR, GM;PRITCHARD, J;VOUTE, PA
通讯作者：
VOUTE, PA
影响因子：
158.5
作者：
Maris, John M.;Mosse, Yael P.;Hakonarson, Hakon
通讯作者：
Hakonarson, Hakon
影响因子：
2.4
作者：
Malek, Marcus M.;Mollen, Kevin P.;Irwin, Chetan
通讯作者：
Irwin, Chetan
DOI：
10.1007/978-1-4419-6033-7_4
发表时间：
2010-01-01
期刊：
CANCER GENETICS-BK
影响因子：
--
作者：
Capasso, Mario;Diskin, Sharon J.
通讯作者：
Diskin, Sharon J.