Clinical outcomes after local field conformal reirradiation of patients with retropharyngeal nodal metastasis
Clinical outcomes after local field conformal reirradiation of patients with retropharyngeal nodal metastasis
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DOI：
10.1002/hed.24872
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发表时间：
2017-10-01
影响因子：
2.9
通讯作者：
Phan, Jack
中科院分区：
文献类型：
--
作者：
Pollard, Courtney, III;Nguyen, Theresa P.;Phan, Jack
背景：本研究的目的是介绍我们使用高度适形放射治疗 (RT) 进行咽后淋巴结再照射的经验。方法：对 2005 年至 2015 年间 2504 名连续接受放射治疗的头颈部恶性肿瘤患者进行回顾性筛选，确定了 19 名因咽后淋巴结转移而接受再照射的患者。对这些患者的临床和毒性结果进行了评估。结果：13 名患者 (68%) 患有鳞状细胞癌。 11 名患者 (58%) 接受传统分割调强放射治疗 (IMRT) 或质子治疗，8 名患者 (42%) 接受单分割或大分割立体定向放疗。 14 名患者（74%）接受了化疗。中位随访时间为 14.7 个月。 1年局部控制、局部区域控制、总生存率和无进展生存率分别为100%、94%、92%和92%。 3 名患者 (16%) 经历了急性 3 级毒性，发生在接受 IMRT 治疗的患者中。没有出现晚期 3 级毒性。结论：采用适形治疗的咽后淋巴结再照射耐受性良好，并且与良好的短期疾病控制相关。
Background: The purpose of this study was to present our experience with retropharyngeal node reirradiation using highly conformal radiotherapy (RT).Methods: A retrospective screen of 2504 consecutively irradiated patients with head and neck malignancies between 2005 and 2015 identified 19 patients who underwent reirradiation for retropharyngeal node metastasis. Clinical and toxicity outcomes were assessed in these patients.Results: Thirteen patients (68%) had squamous cell carcinoma. Eleven patients (58%) received conventionally fractionated intensity-modulated radiotherapy (IMRT) or proton therapy, and 8 patients (42%) received single-fractionated or hypofractionated stereotactic RT. Fourteen patients (74%) received chemotherapy. Median follow-up was 14.7 months. The 1-year local control, locoregional control, overall survival, and progression-free survival rates were 100%, 94%, 92%, and 92%, respectively. Three patients (16%) experienced acute grade 3 toxicity and occurred in those treated with IMRT. There was no late grade 3 toxicity.Conclusion: Retropharyngeal node reirradiation with conformal therapy is well tolerated and associated with excellent short-term disease control.