Dynamics of the EEG slow-wave synchronization during sleep
Dynamics of the EEG slow-wave synchronization during sleep
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DOI：
10.1016/j.clinph.2005.08.013
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发表时间：
2005-12-01
影响因子：
4.7
通讯作者：
Stam, CJ
中科院分区：
文献类型：
--
作者：
Ferri, R;Rundo, F;Stam, CJ
目的：研究健康正常人睡眠时不同头皮电极记录的慢波活动空间同步动态。方法：采用同步似然（SL）算法对5名健康受试者睡眠时（0.25 ~ 2.5 Hz频段）不同程度的脑电图同步进行表征，并采用去趋势波动分析（DFA）分析其长期时间相关性。结果：我们发现，在“循环交替模式”（CAP）睡眠期间，区域间同步水平高于非CAP睡眠，其a期和B期之间存在微小但显著的差异。CAP期间的SL出现波动，可能与单个EEG慢波元相对应。DFA显示，在SL水平波动随时间尺度变化的双对数图中存在两个线性标度区。这表明在潜在动力学中存在一个特征时间尺度，在不同受试者之间非常稳定（1.23-1.33秒）。我们还计算了两个标度区域的DFA指数：第一个值接近1.5，对应于周期为0.09-0.75 s的波动；第二个值接近1，对应于周期为1.5-24.0 s的波动。只有第一个指数在不同的睡眠阶段显示不同的值。结论：各睡眠阶段和CAP条件在睡眠脑电图同步过程中的作用不同，呈现出复杂的时间结构及其神经生理机制。意义：空间脑电图同步的极慢振荡可能在睡眠期间的长时间脑电图相关中起关键作用，这可能是维持和纠正夜间睡眠结构复杂发展的事件链。(c) 2005年国际临床神经生理学联合会。爱思唯尔爱尔兰有限公司出版。版权所有。
Objective: To study the dynamics of spatial synchronization of the slow-wave activity recorded from different scalp electrodes during sleep in healthy normal controls.Methods: We characterized the different levels of EEG synchronization during sleep (in the 0.25-2.5 Hz band) of five healthy subjects by means of the synchronization likelihood (SL) algorithm and analyzed its long-range temporal correlations by means of the detrended fluctuation analysis (DFA).Results: We found higher-levels of interregional synchronization during 'cyclic alternating pattern' (CAP) sleep than during nonCAP with a small but significant difference between its A and B phases. SL during CAP showed fluctuations probably corresponding to the single EEG slow-wave elements. DFA showed the presence of two linear scaling regions in the double-logarithmic plot of the fluctuations of SL level as a function of time scale. This indicates the presence of a characteristic time scale in the underlying dynamics which was very stable among the different subjects (1.23-1.33 s). We also computed the DFA exponent of the two scaling regions: the first, with values approximate to 1.5, corresponded to fluctuations with period 0.09-0.75 s and the second, with values approximate to 1, corresponded to fluctuations with period 1.5-24.0 s. Only the first exponent showed different values during the different sleep stages.Conclusions: All these results indicate a different role for each sleep stage and CAP condition in the EEG synchronization processes of sleep which show a complex time structure correlated with its neurophysiological mechanisms.Significance: Very slow oscillations in spatial EEG synchronization might play a critical role in the long-range temporal EEG correlations during sleep which might be the chain of events responsible for the maintenance and correct complex development of sleep structure during the night. (c) 2005 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.