Proinflammatory cytokines and elastase-α-1-antitrypsin in Argentine hemorrhagic fever
Proinflammatory cytokines and elastase-α-1-antitrypsin in Argentine hemorrhagic fever
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DOI：
10.4269/ajtmh.1999.60.85
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发表时间：
1999-01-01
影响因子：
3.3
通讯作者：
Molinas, FC
中科院分区：
文献类型：
--
作者：
Marta, RF;Montero, VS;Molinas, FC
阿根廷出血热是由朱宁病毒引起的一种疾病。在急性期，患者表现为血液学和神经系统受累，干扰素-α 1和肿瘤坏死因子-α（TNF-α）水平较高。研究了19例确诊为AHF的患者：6例重度，4例中度和9例轻度病例。ELISA法测定血清白细胞介素6（IL-6）、IL-6可溶性受体（IL-6sR）、IL-8、IL-10和弹性蛋白酶-α 1-抗胰蛋白酶复合物（E-α 1AT）水平。IL-6、IL-8和IL-10水平分别在9例、12例和13例患者中较高，而IL-6sR水平在2例患者中较高，在1例患者中较低。7例患者的E-alpha 1AT水平升高。IL-8和IL-10水平与TNF-α水平以及IL-8和E-α 1AT水平之间存在显著相关性。这些数据证明了促炎和抗炎细胞因子途径的激活，并且统计分析显示了疾病的临床形式之间的差异。这项研究表明，IL-8在AHF患者的中性粒细胞活化中起着重要作用，正如在其他感染性疾病中所证明的那样。
Argentine hemorrhagic fever (AHF) is a disease caused by Junin virus. In the acute phase, patients present hematologic and neurologic involvement with high levels of interferon-alpha 1 and tumor necrosis factor-alpha (TNF-alpha). Nineteen patients with a confirmed diagnosis of AHF were studied: six severe, four moderate and nine mild cases. Serum levels of interleukin-6 (IL-6), IL-6 soluble receptor (IL-6sR), IL-8, IL-10, and elastase-alpha 1-antitrypsin complex (E-alpha 1AT) were assayed by ELISAs. Levels of IL-6, IL-8, and IL-10 were high in nine, 12, and 13 patients, respectively, while levels of IL-6sR were high in two patients and low in one patient. Seven patients had increased levels of E-alpha 1AT. Significant correlations were found between levels of both IL-8 and IL-10 with those of TNF-alpha as well as between IL-8 and E-alpha 1AT. These data demonstrate activation of pro-inflammatory and anti-inflammatory cytokine pathways, and statistical analysis showed differences among the clinical forms of illness. This study shows that IL-8 plays an essential role in neutrophil activation in AHF patients as demonstrated in other infectious diseases.