Simple paper architecture modifications lead to enhanced sensitivity in nanoparticle based lateral flow immunoassays
Simple paper architecture modifications lead to enhanced sensitivity in nanoparticle based lateral flow immunoassays
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DOI：
10.1039/c2lc41144j
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发表时间：
2013-01-01
期刊：
影响因子：
6.1
通讯作者：
Merkoci, Arben
中科院分区：
文献类型：
--
作者：
Parolo, Claudio;Medina-Sanchez, Mariana;Merkoci, Arben
侧流免疫分析（LFIA）是检测蛋白质的理想生物传感器，但其缺乏灵敏度阻碍了其广泛应用。我们报告了一种策略，通过改变垫的尺寸，可以使基于金纳米颗粒的LFIA的灵敏度提高8倍。所开发的LFIA结构的理论流动模拟与实验结果是一致的。
Lateral flow immunoassays (LFIA) are ideal biosensors to detect proteins, but their lack of sensitivity hinders their extensive use. We report a strategy that yields up to an 8-fold improvement in the sensitivity of a gold nanoparticles-based LFIA by changing the sizes of the pads. Theoretical flow simulations of the developed LFIA architectures are in accordance with the experimental results.