Recent developments in implantable neural probe technologies
Recent developments in implantable neural probe technologies
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DOI：
10.1557/s43577-023-00535-2
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发表时间：
2023-05-12
期刊：
影响因子：
5
通讯作者：
Fang, Ying
中科院分区：
文献类型：
--
作者：
Chen, Hongyu;Fang, Ying
了解神经回路功能需要能够在较长时间内询问大量神经元活动的工具。植入式神经探针能够以高时空分辨率记录和调节神经元的活动，是基础和应用神经科学中应用最广泛的工具之一。在过去的十年中，植入式神经探针技术在能力和可靠性方面有了很大的发展。本文重点介绍先进材料和加工策略支持的植入式神经探针技术的最新发展。我们强调植入式神经探针，可以允许大规模和持久的神经活动记录。此外，我们描述了最近的发展，在多功能神经探头相结合的电生理记录和调制功能。这些技术的广泛传播和临床转化将迅速推进我们对大脑的理解，并为神经系统疾病的治疗提供新的机会。
Understanding neural circuit functions requires tools that can interrogate the activity of a large number of neurons over extended periods of time. Implantable neural probes can record and modulate neuronal activities at high spatiotemporal resolution, representing one of the most applied tools in basic and applied neuroscience. Over the past decade, implantable neural probe technologies have evolved considerably in terms of capability and reliability. This article focuses on the latest developments in implantable neural probe technologies that are enabled by advanced materials and processing strategies. We highlight implantable neural probes that can allow for large-scale and long-lasting neural activity recordings. In addition, we describe recent developments in multifunctional neural probes for combined electrophysiological recording and modulation functionalities. The wide dissemination and clinical translation of these technologies will rapidly advance our understanding of the brain and provide new opportunities for the treatment of neurological diseases.