Major dietary patterns are related to plasma concentrations of markers of inflammation and endothelial dysfunction
Major dietary patterns are related to plasma concentrations of markers of inflammation and endothelial dysfunction
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DOI：
10.1093/ajcn/80.4.1029
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发表时间：
2004-10-01
影响因子：
7.1
通讯作者：
Hu, FB
中科院分区：
文献类型：
--
作者：
Lopez-Garcia, E;Schulze, MB;Hu, FB
背景资料：内皮功能障碍是饮食与心血管疾病风险之间的联系机制之一。目的：我们评估了饮食模式（食物消耗的概括测量）与炎症和内皮功能障碍的标志物直接相关，特别是C-反应蛋白（CRP）、白细胞介素6、E-选择素、可溶性细胞间粘附分子I（sICAM-1），和可溶性血管细胞粘附分子I（sVCAM-1）。设计：我们对来自护士健康研究I队列的732名妇女进行了横断面研究，她们年龄在43-69岁之间，在1990年抽血时没有心血管疾病、癌症和糖尿病。饮食摄入量记录使用一个有效的食物频率问卷在1986年和1990年。饮食模式产生的因素analysis.Results：一个谨慎的模式，其特点是较高的水果，蔬菜，豆类，鱼类，家禽和全谷物的摄入量，和西方模式的特点是较高的摄入量的红色和加工肉类，糖果，甜点，薯条，精制谷物。在校正年龄、体重指数（BMI）、体力活动、吸烟状况和饮酒量后，谨慎模式与CRP（P = 0.02）和E-选择素（P = 0.001）的血浆浓度呈负相关。Western图谱与CRP呈正相关（P < 0.001），白细胞介素6（P = 0.006），E-选择素（P < 0.001）、sICAM-1（P < 0.001），和sVCAM-1（P = 0.008）调整除BMI以外的所有混杂因素后;随着BMI的进一步调整，CRP的系数仍然显著（P = 0.02），E-选择素（P < 0.001）、sICAM-1（P = 0.002）和sVCAM-1（P = 0.02）。结论：因为内皮功能障碍是动脉粥样硬化发展的早期步骤，这项研究提出了饮食模式在心血管疾病发病机制中的作用机制。
Background: Endothelial dysfunction is one of the mechanisms linking diet and the risk of cardiovascular disease.Objective: We evaluated the hypothesis that dietary patterns (summary measures of food consumption) are directly associated with markers of inflammation and endothelial dysfunction, particularly C-reactive protein (CRP), interleukin 6, E-selectin, soluble intercellular adhesion molecule I (sICAM-1), and soluble vascular cell adhesion molecule I (sVCAM-1).Design: We conducted a cross-sectional study of 732 women from the Nurses' Health Study I cohort who were 43-69 y of age and free of cardiovascular disease, cancer, and diabetes mellitus at the time of blood drawing in 1990. Dietary intake was documented by using a validated food-frequency questionnaire in 1986 and 1990. Dietary patterns were generated by using factor analysis.Results: A prudent pattern was characterized by higher intakes of fruit, vegetables, legumes, fish, poultry, and whole grains, and a Western pattern was characterized by higher intakes of red and processed meats, sweets, desserts, French fries, and refined grains. The prudent pattern was inversely associated with plasma concentrations of CRP (P = 0.02) and E-selectin (P = 0.001) after adjustment for age, body mass index (BMI), physical activity, smoking status, and alcohol consumption. The Western pattern showed a positive relation with CRP (P < 0.001), interleukin 6 (P = 0.006), E-selectin (P < 0.001), sICAM-1 (P < 0.001), and sVCAM-1 (P = 0.008) after adjustment for all confounders except BMI; with further adjustment for BMI, the coefficients remained significant for CRP (P = 0.02), E-selectin (P < 0.001), sICAM-1 (P = 0.002), and sVCAM-1 (P = 0.02).Conclusion: Because endothelial dysfunction is an early step in the development of atherosclerosis, this study suggests a mechanism for the role of dietary patterns in the pathogenesis of cardiovascular disease.