Impact of CPAP on Activity Patterns and Diet in Patients with Obstructive Sleep Apnea (OSA)
Impact of CPAP on Activity Patterns and Diet in Patients with Obstructive Sleep Apnea (OSA)
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DOI：
10.5664/jcsm.3686
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发表时间：
2014-01-01
影响因子：
4.3
通讯作者：
Quan, Stuart F.
中科院分区：
文献类型：
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作者：
Batool-Anwar, Salma;Goodwin, James L.;Quan, Stuart F.
研究目的：重度OSA患者消耗更多的胆固醇、蛋白质和脂肪，以及更多的热量消耗。然而，目前尚不清楚他们的活动水平或饮食是否在CPAP治疗后发生变化。为了调查这个问题，系列活动和饮食摄入量的评估进行了呼吸暂停正压长期疗效研究（APPLES）; 6个月的随机对照研究CPAP与假CPAP对neurocognitive outcome.Methods：受试者被招募到APPLES在5个网站通过诊所遇到或公共广告。在接受诊断性多导睡眠图检查后，如果AHI>= 10，受试者被随机分配到CPAP或假手术组。使用器械的数据卡评估依从性。在图森和瓦拉瓦拉网站，受试者被要求在基线和4个月vision.Results完成验证活动和食物频率问卷：活动和饮食数据可在基线和4个月后治疗CPAP或假多达231名（117 CPAP，114假）。该队列的平均年龄、AHI、BMI和埃普沃思嗜睡评分（ESS）分别为55 ± 13 [SD]岁、44 ± 27/h、33 ± 7.8 kg/m2和10 ± 4。缺乏活动和饮食数据的参与者更年轻，AHI和唤醒指数更低，睡眠效率更好（p <0.05）。CPAP组和Sham组女性的BMI均较高。然而，与女性相比，男性仅在CPAP组中具有更高的AHI（50 vs. 34）。同样，CPAP组男性的唤醒指数较高。CPAP组男性患者的依从性水平（定义为4个月时每晚使用器械的小时数）显著更高（4.0 +/-2.9 vs. 2.6 +/-2.6）。4个月后，总热量、蛋白质、碳水化合物或脂肪的消耗量没有变化。除了女性的娱乐活动适度增加（268 +/-85对170 +/-47卡路里，p <0.05），活动模式也没有变化。结论：除了女性的娱乐活动适度增加，CPAP治疗的OSA患者在治疗后基本上没有改变他们的饮食或身体活动习惯。
Study Objectives: Patients with severe OSA consume greater amounts of cholesterol, protein, and fat as well as have greater caloric expenditure. However, it is not known whether their activity levels or diet change after treatment with CPAP. To investigate this issue, serial assessments of activity and dietary intake were performed in the Apnea Positive Pressure Long-term Efficacy Study (APPLES); a 6-month randomized controlled study of CPAP vs. sham CPAP on neurocognitive outcomes.Methods: Subjects were recruited into APPLES at 5 sites through clinic encounters or public advertisement. After undergoing a diagnostic polysomnogram, subjects were randomized to CPAP or sham if their AHI was >= 10. Adherence was assessed using data cards from the devices. At the Tucson and Walla Walla sites, subjects were asked to complete validated activity and food frequency questionnaires at baseline and their 4-month visit.Results: Activity and diet data were available at baseline and after 4 months treatment with CPAP or sham in up to 231 subjects (117 CPAP, 114 Sham). Mean age, AHI, BMI, and Epworth Sleepiness Score (ESS) for this cohort were 55 +/- 13 [SD] years, 44 +/- 27 /h, 33 +/- 7.8 kg/m(2), and 10 +/- 4, respectively. The participants lacking activity and diet data were younger, had lower AHI and arousal index, and had better sleep efficiency (p < 0.05). The BMI was higher among women in both CPAP and Sham groups. However, compared to women, men had higher AHI only in the CPAP group (50 vs. 34). Similarly, the arousal index was higher among men in CPAP group. Level of adherence defined as hours of device usage per night at 4 months was significantly higher among men in CPAP group (4.0 +/- 2.9 vs. 2.6 +/- 2.6). No changes in consumption of total calories, protein, carbohydrate or fat were noted after 4 months. Except for a modest increase in recreational activity in women (268 +/- 85 vs. 170 +/- 47 calories, p < 0.05), there also were no changes in activity patterns.Conclusion: Except for a modest increase in recreational activity in women, OSA patients treated with CPAP do not substantially change their diet or physical activity habits after treatment.