THE EFFECTS OF MODERATE COOLING ON GROSS COCHLEAR POTENTIALS IN THE GERBIL - BASAL AND APICAL DIFFERENCES
THE EFFECTS OF MODERATE COOLING ON GROSS COCHLEAR POTENTIALS IN THE GERBIL - BASAL AND APICAL DIFFERENCES
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DOI：
10.1016/0378-5955(92)90076-y
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发表时间：
1992-11-01
期刊：
影响因子：
2.8
通讯作者：
SIEGEL, JH
中科院分区：
文献类型：
--
作者：
OHLEMILLER, KK;SIEGEL, JH
在低于正常体温7-8摄氏度的均匀降温过程中，监测了沙土鼠复合动作电位(CAP)对低频和高频短纯音反应阈值的变化。在相同条件下，记录耳蜗底和尖部的内耳电位(EP)、微音器电位(CM)和总和电位(SP)。与降温有关的CAP变化，以及在记录位置最佳频率附近获得的CM和SP响应，在底部比在尖端更大。相反，EP的减少在整个耳蜗区似乎是一致的。因此，基底CAP阈值的较大脆弱性并不是由于该区域血管纹的较大脆弱性造成的。我们的结果表明，耳蜗基底部CAP对降温的敏感性增强反映了毛细胞机制的变化。
Changes in the threshold of the compound action potential (CAP) response in the gerbil to low- and high-frequency tonebursts were monitored during uniform cooling of the cochlea by 7-8-degrees-C below normal body temperature. Recordings of the endocochlear potential (EP), cochlear microphonic (CM), and summating potentials (SP) were also obtained from the base and apex of the cochlea under the same conditions. Cooling-related changes in the CAP, as well as the CM and SP response obtained near the best frequency of the recording location, were greater in the base than in the apex. In contrast, reductions in the EP appeared uniform throughout the cochlea. Thus the greater vulnerability of CAP thresholds in the base does not result from a greater vulnerability of the stria vascularis in this region. Our results suggest that the enhanced susceptibility to cooling of the CAP in the cochlear base reflects changes in hair cell mechanisms.