Mind the gap - Managing tuberculosis across the disease spectrum.
Mind the gap - Managing tuberculosis across the disease spectrum.
复制标题
DOI：
10.1016/j.ebiom.2022.103928
复制
发表时间：
2022-04
期刊：
影响因子：
11.1
通讯作者：
Houben, Rein M. G. J.
中科院分区：
文献类型：
--
作者：
Esmail, Hanif;Macpherson, Liana;Coussens, Anna K.;Houben, Rein M. G. J.
我们目前有一个二项式的方法来管理结核病。那些患有活动性疾病的人，理想情况下，微生物学证实，用标准的6个月，多药物方案治疗，那些潜伏感染和没有疾病证据的人用较短的，一种或两种药物方案治疗。临床医生经常遇到介于这两种管理途径之间的患者，这些患者具有一些但不是全部疾病特征，随着越来越重视基于胸部X线的系统筛查，这种情况将更常见。结核病作为一系列疾病状态的观点正日益得到认可，并导致新的早期疾病诊断方法。然而，治疗疾病的6个月方案是由治疗最广泛形式的肺结核所需的持续时间决定的，较短的持续时间似乎足以治疗不太广泛的疾病。现在是时候进行临床试验，以更好地确定结核病的最佳治疗方法。
We currently have a binomial approach to managing tuberculosis. Those with active disease, ideally confirmed microbiologically, are treated with a standard 6-month, multi-drug regimen and those with latent infection and no evidence of disease with shorter, one or two drug regimens. Clinicians frequently encounter patients that fall between these two management pathways with some but not all features of disease and this will occur more often with the increasing emphasis on chest X-ray-based systematic screening. The view of tuberculosis as a spectrum of disease states is being increasingly recognised and is leading to new diagnostic approaches for early disease. However, the 6-month regimen for treating disease was driven by the duration required to treat the most extensive forms of pulmonary TB and shorter durations appear sufficient for less extensive disease. It is time undertake clinical trials to better define the optimal treatment for tuberculosis across the disease spectrum.
登录
查看更多内容
影响因子：
82.9
作者：
Esmail, Hanif;Lai, Rachel P.;Lesosky, Maia;Wilkinson, Katalin A.;Graham, Christine M.;Coussens, Anna K.;Oni, Tolu;Warwick, James M.;Said-Hartley, Qonita;Koegelenberg, Coenraad F.;Walzl, Gerhard;Flynn, JoAnne L.;Young, Douglas B.;Barry, Clifton E., III;O'Garra, Anne;Wilkinson, Robert J.
通讯作者：
Wilkinson, Robert J.
影响因子：
3.7
作者：
Blankley S;Graham CM;Turner J;Berry MP;Bloom CI;Xu Z;Pascual V;Banchereau J;Chaussabel D;Breen R;Santis G;Blankenship DM;Lipman M;O'Garra A
通讯作者：
O'Garra A
DOI：
10.1098/rstb.2013.0437
发表时间：
2014
期刊：
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
影响因子：
--
作者：
Esmail H;Barry CE 3rd;Young DB;Wilkinson RJ
通讯作者：
Wilkinson RJ
DOI：
10.1016/s2666-5247(21)00058-6
发表时间：
2021-10
期刊：
The Lancet. Microbe
影响因子：
--
作者：
Chen RY;Yu X;Smith B;Liu X;Gao J;Diacon AH;Dawson R;Tameris M;Zhu H;Qu Y;Zhang R;Pan S;Jin X;Goldfeder LC;Cai Y;Arora K;Wang J;Vincent J;Malherbe ST;Thienemann F;Wilkinson RJ;Walzl G;Barry CE 3rd
通讯作者：
Barry CE 3rd
DOI：
10.1093/cid/ciaa1402
发表时间：
2021-08-02
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Frascella B;Richards AS;Sossen B;Emery JC;Odone A;Law I;Onozaki I;Esmail H;Houben RMGJ
通讯作者：
Houben RMGJ