A SU-8-Based Fully Integrated Biocompatible Inductively Powered Wireless Neurostimulator
A SU-8-Based Fully Integrated Biocompatible Inductively Powered Wireless Neurostimulator
复制标题
DOI：
10.1109/jmems.2012.2221155
复制
发表时间：
2013-02-01
影响因子：
2.7
通讯作者：
Lee, Jeong-Bong
中科院分区：
文献类型：
--
作者：
Cho, Sung-Hoon;Xue, Ning;Lee, Jeong-Bong
设计、制造了一种完全集成的微创紧凑型聚合物无线神经刺激器，并在露天和体内进行了表征。神经刺激器（3.1 x 1.6 x 0.3 mm）由一个平面螺旋线圈（用于通过电感耦合进行无线供电）、两个肖特基二极管（用于全波整流）、一个专用集成电路神经刺激器电路芯片（用于产生刺激尖峰信号）和两个双相铂铱（PtIr）刺激电极组成。该器械完全集成并完全嵌入生物相容性SU-8包装中。对于体内测试，将无线神经刺激器皮下植入大鼠后肢。在394-MHz谐振频率下，在21 dBm（125 mW）的耦合功率下，记录了在延长的无线刺激期间稳定和稳健的皮质反应。
A fully integrated minimally invasive compact polymer-based wireless neurostimulator was designed, fabricated, and characterized both in open air and in vivo. The neurostimulator (3.1 x 1.6 x 0.3 mm) consists of a planar spiral coil for wireless power supply through inductive coupling, two Schottky diodes for full-wave rectification, an application-specific integrated circuit neurostimulator circuit chip for stimulus spike signal generation, and two biphasic platinum-iridium (PtIr) stimulation electrodes. The device is fully integrated and completely embedded in biocompatible SU-8 packaging. For in vivo testing, the wireless neurostimulator was implanted subcutaneously in a rat hind limb. At the coupling power of 21 dBm (125 mW) at 394-MHz resonant frequency, stable and robust cortical responses during extended periods of wireless stimulation were recorded.