Homologous HSV1 and alpha-synuclein peptides stimulate a T cell response in Parkinson's disease
Homologous HSV1 and alpha-synuclein peptides stimulate a T cell response in Parkinson's disease
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DOI：
10.1016/j.jneuroim.2017.06.004
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发表时间：
2017-09-15
影响因子：
3.3
通讯作者：
Sechi, L. A.
中科院分区：
文献类型：
--
作者：
Caggiu, E.;Paulus, K.;Sechi, L. A.
环境因素与帕金森病（PD）的发展有关。本研究的目的是通过使用细胞内细胞因子方法对帕金森病患者和健康对照研究细胞介导的免疫对 HSV-1 和人 α-突触核蛋白同源肽的特异性免疫刺激的作用。该研究首次表明，PD 患者在刺激后对 TNF-α CD8、CD4 和 NK 细胞产生特异性反应。我们的数据表明免疫系统在帕金森病的发病机制中可能发挥作用，并且 HSV-1 感染可能会导致疾病的进展。
Environmental factors are implicated in the development of Parkinson's disease (PD). The aim of this study is to investigate the role of cell-mediated immunity upon a specific immune-stimulation with HSV-1 and human alpha-synuclein homologues peptides by using the intracellular cytokine method on Parkinson's patients and healthy controls. The study showed, for the first time, a specific response to TNF-alpha CD8, CD4 and NK cells after stimulation in PD patients. Our data show a possible role of the immune system in the pathogenesis of Parkinson's disease, and that HSV-1 infections may lead to a progression of the disease.