CD8+T-cell mediated self-reactivity in HLA-B27 context as a consequence of dual peptide conformation
CD8+T-cell mediated self-reactivity in HLA-B27 context as a consequence of dual peptide conformation
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DOI：
10.1016/j.clim.2010.01.009
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发表时间：
2010-06-01
影响因子：
8.6
通讯作者：
Fiorillo, Maria Teresa
中科院分区：
文献类型：
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作者：
Nurzia, Elisa;Panimolle, Francesca;Fiorillo, Maria Teresa
HLA-B*2709与B*2705（不同人种中最常见且与as相关的亚型）不同，但不易患强直性脊柱炎，仅替代His116Asp。因此，对这些等位基因B*2705进行比较可能是阐明该疾病分子机制的有效方法，B*2705已被证明在基本残基（即pVIPR和pGR）中以双重构象显示某些丰富的自肽，并且伴随着特异性细胞毒性T细胞的存在。在这项研究中，我们证实了我们之前的观察，即B*2709健康受试者对pVIPR不具有原发性反应性，但在pGR驱动下表现出CD8+ T细胞的快速反应。值得注意的是，在B*2709的呈现环境中，pVIPR只有一个单一的构象，而pGR是二态的。这些结果表明双肽构象的发生与诱导特异性自身免疫反应的性质之间可能存在普遍联系(C) 2010 Elsevier Inc .版权所有。
HLA-B*2709 does not predispose for Ankylosing Spondylitis although it differs from B*2705, the most common and AS-associated subtype in different ethnic groups, only for the substitution His116Asp. Therefore, a productive approach to elucidate the molecular mechanisms of the disease could be the comparison of these alleles B*2705 has been shown to display certain self-peptides enriched in basic residues i.e., pVIPR and pGR, in a dual conformation and this is accompanied by the presence of specific cytotoxic T cells in patients with AS. In this study, we convalidate our previous observation that B*2709 healthy subjects do not possess primary reactivity towards pVIPR while showing a prompt CD8+ T cell response driven by pGR. Notably, in the B*2709 context of presentation, pVIPR assumes only a single conformation in contrast with pGR which is dimorphic. These results suggest a possible general connection between the occurrence of double peptide conformation and the property of inducing specific autoimmune responses (C) 2010 Elsevier Inc All rights reserved.