PharmGKB: the Pharmacogenomics Knowledge Base.

PharmGKB: the Pharmacogenomics Knowledge Base.
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DOI:
10.1007/978-1-62703-435-7_20
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发表时间:
2013
期刊:
Methods in molecular biology (Clifton, N.J.)
影响因子:
--
通讯作者:
Altman, Russ B
Altman, Russ B
中科院分区:
其他
文献类型:
--
作者:
Thorn, Caroline F;Klein, Teri E;Altman, Russ B

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药物基因组学知识库(PharmGKB)是研究人员用于研究基因变异如何影响药物反应的一种交互式工具。PharmGKB网站(http://www.pharmgkb.org)展示了整合到通路表述中的基因型、分子和临床知识,以及非常重要的药物基因(VIP)概要,并带有指向其他外部资源的链接。用户可以通过基因、变异、药物、疾病和通路来搜索和浏览该知识库。整个研究群体均可免费注册,但需同意仅用于研究目的且不得重新分发。注册用户可以访问和下载数据,以协助未来药物遗传学和药物基因组学研究的设计。
The Pharmacogenomics Knowledge Base, PharmGKB, is an interactive tool for researchers investigating how genetic variation affects drug response. The PharmGKB Web site, http://www.pharmgkb.org, displays genotype, molecular, and clinical knowledge integrated into pathway representations and Very Important Pharmacogene (VIP) summaries with links to additional external resources. Users can search and browse the knowledgebase by genes, variants, drugs, diseases, and pathways. Registration is free to the entire research community, but subject to agreement to use for research purposes only and not to redistribute. Registered users can access and download data to aid in the design of future pharmacogenetics and pharmacogenomics studies.