NMR‐based diffusion pore imaging by double wave vector measurements
NMR‐based diffusion pore imaging by double wave vector measurements
复制标题
基于 NMR 的双波矢量测量扩散孔成像
DOI：
10.1002/mrm.24515
复制
发表时间：
2012
影响因子：
3.3
通讯作者：
F. Laun
中科院分区：
文献类型：
--
作者：
T. Kuder;F. Laun
核磁共振（NMR）扩散实验的一个主要兴趣是研究边界，如细胞膜阻碍扩散过程。NMR扩散测量允许从整个样品收集信号。这主要消除了在增加分辨率时信号消失的问题。这一直是一个长期存在的问题，如果在原则上，封闭的孔隙的确切形状可以通过NMR扩散测量确定。在这项工作中，我们提出了一种方法，仅使用短扩散梯度脉冲，这是能够揭示任意封闭的孔隙的形状，而不依赖于先验知识。与以前的方法相比，该方法由于更快地收敛到扩散长时间限制而降低了对弛豫时间的要求，并且允许更灵活的NMR序列设计，因为例如，可以使用受激回波。Magn Reson Med 70：836-841，2013。© 2012 Wiley Periodicals，Inc.
One main interest of nuclear magnetic resonance (NMR) diffusion experiments is the investigation of boundaries such as cell membranes hindering the diffusion process. NMR diffusion measurements allow collecting the signal from the whole sample. This mainly eliminates the problem of vanishing signal at increasing resolution. It has been a longstanding question if, in principle, the exact shape of closed pores can be determined by NMR diffusion measurements. In this work, we present a method using short diffusion gradient pulses only, which is able to reveal the shape of arbitrary closed pores without relying on a priori knowledge. In comparison to former approaches, the method has reduced demands on relaxation times due to faster convergence to the diffusion long‐time limit and allows for a more flexible NMR sequence design, because, e.g., stimulated echoes can be used. Magn Reson Med 70:836–841, 2013. © 2012 Wiley Periodicals, Inc.