Epileptiform mice, a new neurological mutant.
Epileptiform mice, a new neurological mutant.
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癫痫样小鼠，一种新的神经突变体。
DOI：
10.1093/oxfordjournals.jhered.a109289
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发表时间：
1979
影响因子：
3.1
通讯作者：
Alberta Shiras Hare
中科院分区：
文献类型：
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作者：
E. Hare;Alberta Shiras Hare
在小鼠身上描述了一种新的突变体，显示出癫痫样发作。这种情况是由常染色体隐性等位基因决定的，外显率超过90%。癫痫样的名字和为这种突变提出的象征性事件。首次出现癫痫行为的时间从第20天到晚至14个月不等，98%的人在140天时开始抽搐。生活跨度正常(平均11.6个月)。EPF/EPF母鼠的平均产仔数为4.04±1.7S.D.，epf/epf雄×+/EPF母鼠配对的平均产仔数为6.2±2.7S.d。杂合子动物看起来正常，癫痫样小鼠与未患癫痫的小鼠除了癫痫易感性外，没有明显的区别。癫痫发作可由一系列轻微刺激引起，包括生理、视觉和听觉刺激。受试者在休息一段时间后最容易受到影响。发作模式包括紧张期、阵挛期和发作后恢复期。紧张期包括所有四肢的强烈毒性屈曲和伸展，通常伴有明显的正直和反强直。克隆期以不同程度的克隆性活动为标志，从四肢抽搐到四肢和尾巴的剧烈拍打运动。受影响的小鼠在一段不同的时间内对额外的癫痫发作难以耐受。致命结果(癫痫持续状态)很少发生(5%)。将癫痫发作模式与其他易发作动物的癫痫发作模式进行了比较，并与人类大发作癫痫作了比较。
A new mutant showing epileptiform seizures is described in mice. The condition is determined by an autosomal recessive allele, with penetrance above 90 percent. The name epileptiform and the symbolepfare proposed for this mutation. First appearance of seizure behavior varies from the 20th day to as late as 14 months, with 98 percent becoming convulsive by the 140th day. Life spanis normal (average, 11.6 months). Average litter size ofepf/epfmothers is 4.04 ± 1.7 S.D. Matings ofepf/epfmales × +/epf females yield an average litter size of 6.2 ± 2.7 S.D. Heterozygous animals appear normal and epileptiform mice are indistinguishable from unaffected litter mates except in seizure susceptibility. Seizures may be induced by a range of mild stimuli, including physical, visual, and auditory. Subjects are most susceptible after a period of rest. The seizure pattern involves a tonic phase, a clonic phase, and a post-ictal recovery period. The tonic phase includes strong toxic flexions and extensions of all four limbs, often with distinct emprosthotonus and opisthotonus of the body. The clonic phase is marked by varying degrees of clonic activity, ranging from limb twitching to violent thrashing movements of limbs and tail. Affected mice are refractory to additional seizures for a varying period of time. Fatal outcome (status epilepticus) occurs rarely (5 percent). Comparisons are made ofepfseizure pattern with those of other seizure prone animals, and with grand mal epilepsy in man.