Decreased body temperature dependent appearance of behavioral despair in the forced swimming test in mice
Decreased body temperature dependent appearance of behavioral despair in the forced swimming test in mice
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DOI：
10.1006/phrs.2000.0672
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发表时间：
2000-08-01
影响因子：
9.3
通讯作者：
Otomo, S
中科院分区：
文献类型：
--
作者：
Arai, I;Tsuyuki, Y;Otomo, S
在小鼠强迫游泳试验中检查了体温对不动反应和脑葡萄糖代谢的影响。第一个实验是为了研究行为，在最初的剧烈活动后，当水温为 25 和 35 摄氏度时，会出现特征性的不动姿势。然而，在 25 摄氏度下强迫游泳几分钟后，自发运动以时间依赖性方式显着下降，但在 35 摄氏度下没有观察到变化。我们的解释是，强迫游泳引起的不动反应的获得和保留机制不同。在强迫游泳测试中，体温在25℃时也有显着降低，但在35℃时则没有。体温的降低几乎与不动反应同时发生。第二个实验是一项生化研究，其中在 25 摄氏度下强迫游泳后，大脑对 [C-14] 2-脱氧-D-葡萄糖的摄取显着减少，但在水温为 35 摄氏度时，强迫游泳负荷小鼠中的摄取量没有变化。这些结果表明强迫游泳测试中存在两种类型的不动机制：（1）早期获得不动反应，这可能与适应性反应有关；（2）后期获得不动反应，这可能与适应性反应有关。大脑葡萄糖代谢下降。 (C) 2000 年学术出版社。
Effects of body temperature on the immobile response and brain glucose metabolism were examined in the forced swimming test in mice. The first experiment was performed to study behavior, after initial periods of vigorous activity, a characteristic immobile posture occurred when the water was 25 and 35 degrees C. However, several minutes after forced swimming at 25 degrees C, significantly decreased spontaneous motility occurred in a time-dependent manner, but no changes was observed at 35 degrees C. Our interpretation was that mechanisms of acquisition and retention of the forced swim-induced immobile response differed. Body temperature was also significantly decreased at 25 degrees C but not at 35 degrees C in the forced swimming test. This lowering of body temperature almost paralleled the immobile response. The second experiment was a biochemical study in which the uptake of [C-14] 2-deoxy-D-glucose into the brain significantly decreased after forced swimming at 25 degrees C but did not change in the forced swim loaded mice when the water was 35 degrees C. These results suggested two types of immobile mechanisms in the forced swimming test: (1) an early phase acquisition of the immobile response which might be related to adaptive response and (2) a late phase to retain the immobile response which might be related to the decrease in brain glucose metabolism. (C) 2000 Academic Press.