Two-dimensional chromatography of complex polymers -: 6.: Method development for (meth)acrylate-based copolymers
Two-dimensional chromatography of complex polymers -: 6.: Method development for (meth)acrylate-based copolymers
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DOI：
10.1016/j.chroma.2008.07.067
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发表时间：
2008-09-05
影响因子：
4.1
通讯作者：
Pasch, Harald
中科院分区：
文献类型：
--
作者：
Raust, Jacques-Antoine;Bruell, Adele;Pasch, Harald
使用不同的色谱技术，包括HPLC和在线耦合二维（2D）液相色谱法的各种丙烯酸酯和甲基丙烯酸酯的自由基共聚，从而产生用于化妆品应用的复杂共聚物进行了研究。通过梯度HPLC实现所有聚合产物的完全分离。一个计算优化程序，使用聚合物色谱模型，使我们能够设计一个步骤移动的相梯度，以提高均聚物色谱分离的分辨率。通过在全自动二维色谱设置中结合梯度HPLC和SEC（尺寸排阻色谱）。化学组成和摩尔质量的复杂分布可以同时描述和指纹。(C)2008 Elsevier B.V.保留所有权利。
The free-radical copolymerisation of various acrylates and methacrylates resulting in complex copolymers for cosmetic applications were investigated using different chromatographic techniques including HPLC and on-line coupled two-dimensional (2D) liquid chromatography. The complete separation of all polymerisation products was achieved by gradient HPLC. A computated optimisation procedure, using the Polymer Chromatographic Model allowed us to design a step mobile phase gradient to improve resolution of homopolymer chromatographic separation. By combining gradient HPLC and SEC(Size Exclusion Chromatography) in a fully automated two-dimensional chromatography setup. the complex distributions of chemical composition and molar mass could be simultaneously described and fingerprinted. (C) 2008 Elsevier B.V. All rights reserved.