Aldehyde Dehydrogenase 1 in Gastric Cancer.
Aldehyde Dehydrogenase 1 in Gastric Cancer.
复制标题
胃癌中的乙醛脱氢酶 1
DOI：
10.1155/2022/5734549
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发表时间：
2022
影响因子：
--
通讯作者：
Zang M
中科院分区：
文献类型：
--
作者：
Wang L;Wang L;Yu Y;Su R;Zhang Y;Li Y;Zang M
胃癌是危害人类健康的重要疾病。因此，阐明GC发展的机制和发现诊断性生物标志物和治疗方法至关重要。醛脱氢酶1（醛脱氢酶1，ALDH1）作为肿瘤干细胞标志物，参与了胃癌的发生、发展和治疗。本文评价了ALDH1的预后价值，并探讨了其在胃癌中的作用机制。重要的是，ALDH1在临床实践中是一种信息丰富的生物标志物，因为它与转移和总生存等指标有特定的关系。此外，ALDH1与基因相互作用，在GC发生和发展的其他机制中表现出模仿干细胞特征的特性。因此，我们的结果为ALDH1作为GC治疗靶点的可能临床应用提供了证据。
Gastric cancer (GC) is a disease that threatens human health. It is thus crucial to clarify the mechanisms involved in GC development and discover diagnostic biomarkers and therapeutics. As a cancer stem cell marker, aldehyde dehydrogenase 1 (ALDH1) is involved in the development, progression, and treatment of GC. This review evaluated the prognostic value of ALDH1 and explored its mechanism of action in GC. Importantly, ALDH1 is an informative biomarker in clinical practice as it has specific relationships with indicators, such as metastasis and overall survival. Additionally, ALDH1 interacts with genes and exhibits properties that mimic stem cell characteristics amongst other mechanisms employed in the occurrence and progression of GC. Our results, therefore, provide evidence of possible clinical utility of ALDH1 as a GC therapeutic target.