Decrease in the volume of white matter lesions with improvement of hepatic encephalopathy
Decrease in the volume of white matter lesions with improvement of hepatic encephalopathy
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DOI：
10.3174/ajnr.a0611
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发表时间：
2007-09-01
影响因子：
3.5
通讯作者：
Cordoba, J.
中科院分区：
文献类型：
--
作者：
Minguez, B.;Rovira, A.;Cordoba, J.
磁共振成像发现与肝性脑病相关的肝硬化患者的脑部存在与低度水肿相符的异常。我们报告了3例肝性脑病患者，他们表现为幕上局灶性或弥漫性白质病变，与小血管脑疾病相一致。随着肝性脑病病情的好转，脑白质病变体积和数量减少，提示血脑屏障参与了肝性脑病脑水肿的发病机制。
MR imaging has found abnormalities compatible with low-grade edema in the brain of patients with cirrhosis that have been related to hepatic encephalopathy. We present 3 patients with hepatic encephalopathy who exhibit supratentorial focal or diffuse white matter lesions compatible with small-vessel brain disease. The volume and number of white matter lesions reduced with the improvement of hepatic encephalopathy, suggesting the participation of the blood-brain barrier in the pathogenesis of brain edema in hepatic encephalopathy.