ROLE OF THE HUMAN ANTERIOR CINGULATE CORTEX IN THE CONTROL OF OCULOMOTOR, MANUAL, AND SPEECH RESPONSES - A POSITRON EMISSION TOMOGRAPHY STUDY
ROLE OF THE HUMAN ANTERIOR CINGULATE CORTEX IN THE CONTROL OF OCULOMOTOR, MANUAL, AND SPEECH RESPONSES - A POSITRON EMISSION TOMOGRAPHY STUDY
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DOI：
10.1152/jn.1993.70.2.453
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发表时间：
1993-08-01
影响因子：
2.5
通讯作者：
MEYER, E
中科院分区：
文献类型：
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作者：
PAUS, T;PETRIDES, M;MEYER, E
1.两个实验旨在研究人类前扣带皮层（ACC）与高阶运动控制相关的功能组织.采用~（15）O标记的H_2O团注法测定18名健康受试者在进行眼动、手动或言语任务时局部脑血流量（rCBF）的相对变化.特定任务的rCBF的变化，在不同的次区域的行政协调会，这取决于所采用的输出系统。眼动和手动任务相关病灶分别位于前扣带回的头侧和尾侧区域，而言语病灶则位于前扣带回的中间背侧和头侧区域。在手动任务中，可以区分两组激活灶，一组位于穿过前连合的垂直平面的后面，另一组位于穿过前连合的垂直平面的前面。只有在外侧前额叶皮层同时激活时才能观察到上述rCBF变化模式（手动任务中获得的后组病灶除外）。人类前扣带回内输出特异性rCBF变化的定位与猴子扣带皮层的已知躯体定位组织一致。初步认为前扣带回通过促进适当反应的执行和/或抑制不适当反应的执行来参与运动控制。当行为在新的和具有挑战性的情况下必须改变时，这种调节作用将特别重要。
1. Two experiments were aimed at investigating the functional organization of the human anterior cingulate cortex (ACC) in relation to higher-order motor control.2. The O-15-labeled H2O bolus method was used to measure relative changes of regional cerebral blood flow (rCBF) in 18 healthy human subjects as they performed oculomotor, manual, or speech tasks.3. Task-specific rCBF changes were obtained in distinct subregions of the ACC, depending on the output system employed. The oculomotor and the manual task-related foci were found in the rostral and caudal regions of the ACC, respectively, whereas the speech foci were localized within two cingulate subregions, the intermediate dorsal and the rostral ACC.4. In the manual tasks, two groups of activation foci could be distinguished, one just behind and the other just in front of the vertical plane traversing the anterior commissure.5. The above pattern of rCBF changes was observed only if there was concomitant activation within the lateral prefrontal cortex (except for the posterior group of foci obtained in the manual tasks).6. The localization of output-specific rCBF changes within the human ACC is consistent with the known somatotopic organization of the cingulate cortex in the monkey.7. It is tentatively proposed that the ACC participates in motor control by facilitating the execution of the appropriate responses and/or suppressing the execution of the inappropriate ones. Such a modulatory effect would be of particular importance when behavior has to be modified in new and challenging situations.