Vascular endothelial growth factor and the eye: Biochemical mechanisms of action and implications for novel therapies
Vascular endothelial growth factor and the eye: Biochemical mechanisms of action and implications for novel therapies
复制标题
DOI：
10.1159/000268033
复制
发表时间：
1997-09-01
影响因子：
2.1
通讯作者：
Aiello, LP
中科院分区：
文献类型：
--
作者：
Aiello, LP
在大多数发达国家，由病理性眼内新生血管引起的眼科并发症是导致大多数视力丧失的原因。与眼内新生血管形成相关的许多疾病包括早产儿视网膜病变、糖尿病视网膜病变和年龄相关性黄斑变性。这些情况分别是婴儿、工作年龄者和老年人失明的主要原因。近半个世纪来，与这些疾病相关的临床发现表明，生长因子的作用可能在这些疾病的发病机制中起关键作用。然而，涉及的确切分子及其作用机制仍不完全清楚。最近，研究已经开始阐明参与调节新生血管性眼病的主要分子和细胞内途径。血管内皮生长因子被认为是眼内新生血管形成和通透性的主要介质。最近对眼内血管生成机制的深入了解为新型非破坏性治疗药物提供了新的靶点，这些药物旨在预防与眼部新生血管性疾病相关的视力丧失。
Ophthalmic complications arising from pathologic intraocular neovascularization are responsible for the majority of visual loss in most developed countries. Among the many disorders associated with intraocular neovascularization are retinopathy of prematurity, diabetic retinopathy and age-related macular degeneration. These conditions are the leading causes of blindness among infants, those of working age and the elderly, respectively. For nearly half a century the clinical findings associated with these conditions have suggested that the action of growth factors may play a pivotal role in the pathogenesis of these diseases. However, the exact molecules involved and their mechanisms of action have remained incompletely understood. Recently, studies have begun to elucidate the major molecules and intracellular pathways involved in regulating neovascular eye disorders. Vascular endothelial growth factor has been implicated as a major mediator of intraocular neovascularization and permeability. The recent insights into the mechanisms of intraocular angiogenesis have provided new targets for novel nondestructive therapeutic agents directed toward preventing the visual loss associated with ophthalmic neovascular disorders.