A comparison of microwave ablation and bipolar radiofrequency ablation both with an internally cooled probe: Results in ex vivo and in vivo porcine livers
A comparison of microwave ablation and bipolar radiofrequency ablation both with an internally cooled probe: Results in ex vivo and in vivo porcine livers
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DOI：
10.1016/j.ejrad.2009.12.009
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发表时间：
2011-07-01
影响因子：
3.3
通讯作者：
Wang, Yang
中科院分区：
文献类型：
--
作者：
Yu, Jie;Liang, Ping;Wang, Yang
目的：本研究的目的是比较微波（MW）消融和射频（RF）消融的有效性，使用一个单一的内部冷却探头在肝猪model.Materials和方法：在离体实验中，微波消融（n = 40）进行了2450 MHz和915 MHz针天线，分别在60 W，70 W的功率设置。根据自动系统功率设置，分别使用3 cm（T30）和4 cm（T40）有源尖端针电极在额定功率30 W和40 W下进行双极射频消融（n = 20）。在体内实验中，进行了60 W的2450 MHz和915 MHz MW消融和30 W的T30双极射频消融（n = 30）。所有的应用时间均为10 min。测量长轴直径（DI）、短轴直径（Ds）、Ds/DI比值、距针5 mm处的温度数据以及距针5 mm处的温度上升到54 ℃的时间。在离体和体内模型中，915 MHz微波消融的Ds和DI均显著大于所有射频消融2450 MHz微波消融的Ds均明显大于T30射频消融的Ds（P < 0.05）。2450 MHz微波和T30射频消融倾向于产生更多的椭圆形消融区。微波消融时距离针头5 mm的组织温度明显更高，同时微波消融比射频消融实现了更快的温度升至54摄氏度的速度。对于消融10分钟后的体内研究，2450 MHz MW、915 MHz MW和双极RF的Ds和DI分别为2.35 +/- 0.75、2.95 +/- 0.32、1.61 +/- 0.33和3.86 +/- 0.81、5.79 +/- 1.03、3.21 +/- 0.51。距针5 mm处的最高组织温度分别为80.07 +/- 12.82 ℃、89.07 +/- 3.52 ℃和65.56 +/- 15.31 ℃，温度升至54 ℃的时间分别为37.50 +/- 7.62 s，三个施加器分别为24.50 +/- 4.09 s和57.29 +/- 23.24 s。结论：微波消融可能比射频消融更有可能完全破坏肝脏肿瘤。(C)2009爱思唯尔爱尔兰有限公司保留所有权利。
Purpose: The purpose of this study was to compare the effectiveness of microwave (MW) ablation and radiofrequency (RF) ablation using a single internally cooled probe in a hepatic porcine model.Materials and methods: In the ex vivo experiment, MW ablations (n = 40) were performed with a 2450 MHz and 915 MHz needle antenna, respectively at 60 W, 70 W power settings. Bipolar RF ablations (n = 20) were performed with a 3-cm (T30) and 4-cm (T40) active tip needle electrodes, respectively at a rated power 30 W and 40 W according to automatically systematic power setting. In the in vivo experiment, the 2450 MHz and 915 MHz MW ablation both at 60 W and T30 bipolar RF ablation at 30 W were performed (n = 30). All of the application time were 10 min. Long-axis diameter (Dl), short-axis diameter (Ds), ratio of Ds/Dl, the temperature data 5 mm from the needle and the time of temperature 5 mm from the needle rising to 54 degrees C were measured.Results: Both in ex vivo and in vivo models, Ds and Dl of 915 MHz MW ablations were significantly larger than all the RF ablations (P < 0.05); the Ds for all the 2450 MHz MW ablations were significantly larger than that of T30 RF ablations (P < 0.05). 2450 MHz MW and T30 RF ablation tended to produce more elliptical-shaped ablation zone. Tissue temperatures 5 mm from the needle were considerably higher with MW ablation, meanwhile MW ablation achieved significantly faster rate of temperature rising to 54 degrees C than RF ablation. For in vivo study after 10 min of ablation, the Ds and Dl of 2450 MHz MW, 915 MHz MW and Bipolar RF were 2.35 +/- 0.75, 2.95 +/- 0.32, 1.61 +/- 0.33 and 3.86 +/- 0.81, 5.79 +/- 1.03, 3.21 +/- 0.51, respectively. Highest tissue temperatures 5 mm from the needle were 80.07 +/- 12.82 degrees C, 89.07 +/- 3.52 degrees C and 65.56 +/- 15.31 degrees C and the time of temperature rising to 54 degrees C were respectively 37.50 +/- 7.62 s, 24.50 +/- 4.09 s and 57.29 +/- 23.24 s for three applicators.Conclusion: MW ablation may have higher potential for complete destruction of liver tumors than RF ablation. (C) 2009 Elsevier Ireland Ltd. All rights reserved.