REMODELING OF THE CONSTITUTIVE EQUATION WHILE A BLOOD-VESSEL REMODELS ITSELF UNDER STRESS
REMODELING OF THE CONSTITUTIVE EQUATION WHILE A BLOOD-VESSEL REMODELS ITSELF UNDER STRESS
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DOI：
10.1115/1.2895523
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发表时间：
1993-11-01
影响因子：
1.7
通讯作者：
ZHOU, JB
中科院分区：
文献类型：
--
作者：
FUNG, YC;LIU, SQ;ZHOU, JB
血管的力学性能的变化时，它重塑自己的压力进行审查。关于血管的最新发现之一是当血压改变时组织重塑的速度。当组织结构和材料成分重塑时，血管的零应力状态发生变化。在重塑过程中，力学性能也发生了变化。如果用拟弹性应变能函数来表示弹性行为，则函数中的常数将在重塑过程中发生变化。随着所有这些变化的发生，本构方程的范围扩大了：它现在应该包括质量和结构的生长应力关系以及应力应变关系。为了获得质量-结构生长-应力关系，必须能够确定血管壁不同层的机械性能以及化学组成和形态。对于血管，必须引入新的力学测试方法。一个关键的想法是利用血管壁的弯曲。通过弯曲，血管壁的不同层受到不同的应力，导致方程可用于解决从测量的应力和应变确定应力-应变定律的逆问题。在体外和体内实验和理论的前瞻性。
Changes in the mechanical properties of a blood vessel when it remodels itself under stress are reviewed. One of the recent findings about blood vessels is the rapidity of tissue remodeling when the blood pressure is changed. When the tissue structure and material composition remodel, the zero-stress state of the vessel changes. The mechanical properties change also in the remodeling process. If the elastic behavior is expressed in terms of a pseudo-elastic strain-energy function, then the constants in the function will change in the course of the remodeling. With all these changes taking place, the scope of constitutive equations broadens: it should now include a mass-and-structure growth-stress relationship as well as a stress-strain-relationship. To obtain the mass-and-structure growth-stress relationship, one must be able to determine the mechanical properties of the different layers of the vessel wall, as well as the chemical composition and morphology. For the blood vessels, new methods of mechanical testing must be introduced. A key thought is to use bending of the blood vessel wall. By bending, different layers of the vessel wall are subjected to different stresses, leading to equations that can be used to solve the inverse problem of determining the stress-strain law from measured stress and strain. In vitro and in vivo experiments and theoretical prospectives are presented.