Intratumoral T cell infiltration, MHC class I and STAT1 as biomarkers of good prognosis in colorectal cancer
Intratumoral T cell infiltration, MHC class I and STAT1 as biomarkers of good prognosis in colorectal cancer
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DOI：
10.1136/gut.2009.194472
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发表时间：
2010-07-01
期刊：
影响因子：
24.5
通讯作者：
Durrant, Lindy G.
中科院分区：
文献类型：
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作者：
Simpson, Jonathan A. D.;Al-Attar, Ahmad;Durrant, Lindy G.
目的探讨免疫监视/编辑技术在结直肠癌治疗中的作用。设计转化可刺激肿瘤细胞产生干扰素γ（IFN γ），并通过肿瘤细胞表面的IFNg受体（IFNGR 1）传递信号。这导致刺激核STAT 1（nSTAT 1），抑制肿瘤生长和上调主要组织相容性复合体（MHC），同时促进T细胞外渗。相比之下，等位基因丢失导致MHC I类下调会导致T细胞识别能力丧失。平均随访42个月（范围1-116）的462个结直肠肿瘤的组织微阵列染色免疫组化标记预测免疫监视/editing.Results的存在下，高水平的肿瘤内T细胞（ITTC）与改善生存相比，低水平的ITTC，平均差异生存16.3个月（p=0.006）。nSTAT 1表达与ITTC呈正相关（p
Objective To evaluate immunosurveillance/editing in colorectal cancer.Design Transformation stimulates the production of interferon gamma (IFN gamma) which signals via the IFNg receptor (IFNGR1) on tumours. This results in stimulation of nuclear STAT1 (nSTAT1), inhibition of tumour growth and upregulation of major histocompatibility complex (MHC) while promoting T cell extravasation. In contrast, downregulation of MHC class I by allele loss results in loss of T cell recognition. A tissue microarray of 462 colorectal tumours with mean follow-up of 42 months (range 1-116) was stained by immunohistochemistry for markers which predict immunosurveillance/editing.Results The presence of a high level of intratumoral T cells (ITTC) correlated with improved survival compared with a low level of ITTC, with a mean difference in survival of 16.3 months (p=0.006). There was a direct correlation between nSTAT1 expression and ITTC (p